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About This Item
经验公式（希尔记法）:
C8H10FNO2S · HCl
CAS号:
分子量:
239.69
Beilstein:
7604627
MDL號碼:
分類程式碼代碼:
12352202
PubChem物質ID:
NACRES:
NA.77
生物源
synthetic (organic)
品質等級
化驗
≥97.0% (HPLC)
形狀
powder
mp
183-191 °C
溶解度
H2O: 50 mg/mL (stable for up to six months if stored refrigerated at a pH of less than 7. If a pH of greater than 7 is required, pH adjustment should be made just prior to use.)
儲存溫度
−20°C
SMILES 字串
FS(C1=CC=C(CCN)C=C1)(=O)=O.[H]Cl
InChI
1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H
InChI 密鑰
WRDABNWSWOHGMS-UHFFFAOYSA-N
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應用
4-（2-氨乙基）苯磺酰氟盐酸盐（AEBSF）已用作：
- 血浆样品中的蛋白酶抑制剂，以防止酰基化胃饥饿素（AG）降解
- SVSP抑制或AEBSF测定中的蛇毒丝氨酸蛋白酶（SVSP）抑制剂，以测定SVSP的参与度对纤维蛋白原凝血活性的影响
- NP-40裂解缓冲液的组分，以重悬细胞微球制备细胞裂解物
建议使用浓度为 0.1 至 1mM。
生化／生理作用
AEBSF可抑制乙酰胆碱酯酶（AChE）。
4-（2-氨乙基）苯磺酰氟盐酸盐（AEBSF）是一种不可逆丝氨酸蛋白酶抑制剂。抑制常数与苯甲磺酰氟（PMSF）和二异丙基氟磷酸（DFP）相似。 经证实，AEBSF可抑制胰蛋白酶、胰凝乳蛋白酶、纤溶酶、激肽释放酶和凝血酶。作为PMSF和DFP的替代品，AEBSF具有较低的毒性，并提高了在水中的溶解性和水溶液中的稳定性。AEBSF可用于浓度高达0.25 mM的细胞培养。
訊號詞
Danger
危險聲明
危險分類
Eye Dam. 1 - Skin Corr. 1A
儲存類別代碼
8A - Combustible, corrosive hazardous materials
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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