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94310

Sigma-Aldrich

尿酸酶 来源于苛求芽胞杆菌

lyophilized, ~9 U/mg

别名:

Urate oxidase

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About This Item

CAS号:
9002-12-4
EC 号:
1.7.3.3 (BRENDA, IUBMB)
MDL號碼:
MFCD00082126
分類程式碼代碼:
12352204
PubChem物質ID:
57653596
NACRES:
NA.54

生物源

Bacillus sp. (B. fastidiosus)

品質等級

300

形狀

powder

品質

lyophilized

比活性

~9 U/mg

儲存條件

dry at room temperature

濃度

90—100%

顏色

white to faint beige

溶解度

5 mg/mL, clear, colorless to very faintly yellow (in enzyme dilution buffer)

應用

detection

儲存溫度

−20°C

SMILES 字串

N.OCC1OC(C(O)C1OP(O)(=O)OCC2OC(C(O)C2O)N3C=CC(=O)NC3=O)N4C=CC(=O)NC4=O

InChI

1S/C18H23N4O14P.H3N/c23-5-7-14(13(28)16(34-7)22-4-2-10(25)20-18(22)30)36-37(31,32)33-6-8-11(26)12(27)15(35-8)21-3-1-9(24)19-17(21)29;/h1-4,7-8,11-16,23,26-28H,5-6H2,(H,31,32)(H,19,24,29)(H,20,25,30);1H3

InChI 密鑰

VPXDHZMLJOJKOX-UHFFFAOYSA-N

一般說明

Research area: Cell signaling
Uricase is present in many organisms, such as, archaea, bacteria, and eukaryotes. The Gut microbiome is the major source of uricase, a homotetrameric enzyme containing four identical 34 kDa subunits.

應用

尿酸酶可用于测定生物液体中的尿酸。可能有助于利用分光光度法测定嘌呤和嘌呤核苷。

生化／生理作用

尿酸酶可催化尿酸氧化为5-羟基异羟乙酸，随后形成（S）-丙氨酸。它可参与嘌呤代谢、尿酸盐降解和（S）-尿囊素的形成 。

單位定義

在pH 9.1和37 °C的条件下，1 U相当于在每分钟内氧化1 μmole 尿酸所需的酶量。

其他說明

用于测定生物液体中的尿酸;用于分光光度法测定嘌呤和嘌呤核苷。

象形圖

Health hazard
GHS08

訊號詞

Danger

危險聲明

H319,H334,H360FD

危險分類

Eye Irrit. 2 - Repr. 1B - Resp. Sens. 1

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

从最新的版本中选择一种：

分析证书(COA)

Lot/Batch Number
BCCF7981
BCCF5418
BCCC7375
BCCB9227
BCBR6597V

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U. Naegele et al.
Methods of Enzymatic Analysis, 7, 140-140 (1985)
M.H. Jensen et al.
Methods of Enzymatic Analysis, 7, 101-101 (1985)
Patrizia Zaramella et al.
Pediatrics, 131(1), e309-e312 (2012-12-05)
This case report describes a preterm newborn infant who was treated with a single dose of rasburicase for an increase in uric acid level. He died on the third day as a result of complications of hemolysis, which appeared to
Sara Cipriani et al.
Journal of neurochemistry, 123(1), 172-181 (2012-06-08)
Urate is the end product of purine metabolism and a major antioxidant circulating in humans. Recent data link higher levels of urate with a reduced risk of developing Parkinson's disease and with a slower rate of its progression. In this
Chia-Ter Chao et al.
Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 21(5), 498-500 (2012-06-13)
To report a case of huge hepatocellular carcinoma associated with tumor lysis syndrome and its management. A 51-year-old hepatitis B carrier visited our clinic with progressive weight loss over recent months. Abdominal ultrasonography and magnetic resonance imaging revealed a huge
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