生物源
bovine milk
種類
Grade IV
形狀
ammonium sulfate suspension
比活性
≥0.1 units/mg protein
儲存溫度
2-8°C
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一般說明
Research area: Cell CycleXanthineoxidase (XO) is a homodimer. It is made up of two sub-units each made up of onemolybdenum and two iron-sulphur (2Fe-2S) centers.
Formerly E.C.1.1.3.22
應用
Xanthine Oxidase from bovine milk has been used in superoxide dismutaseactivity assay.Xanthine oxidase may be suitable for producing amperometric biosensors and designing-flavonoid-type inhibitors against XO for treating inflammatory diseases, gout, and hyperuricemia. It may also be used in the synthesis of superoxide because of aldehyde oxidation.
生化／生理作用
木糖氧化酶是一种含钼酶，存在于细胞质中，能够被黄酮类化合物有效抑制。它在一些药物和嘌呤嘧啶代谢中有重要作用。它被认为是活性氧簇的生物来源。
虽然发现黄嘌呤氧化酶广泛分布于多种组织中，但它在内皮细胞和上皮细胞中高度表达。其在感染组织中的表达也增加，由于其能够产生活性氧，因此显示具有抗微生物作用。
單位定義
在 pH 值为 7.5、25°C 条件下，1 个单位的黄嘌呤每分钟转化为尿酸 1.0 μmol/min。次黄嘌呤作为底物时，可获得约 50% 的活性。
外觀
含 1 mM 水杨酸钠的 2.3 M (NH4)2SO4 混悬液
分析報告
双缩脲法测定蛋白质
訊號詞
Danger
危險聲明
危險分類
Resp. Sens. 1
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
Role of xanthine oxidoreductase as an antimicrobial agent.
Hannah M Martin et al.
Infection and immunity, 72(9), 4933-4939 (2004-08-24)
Xiaoqiang Chen et al.
Nature protocols, 11(7), 1219-1228 (2016-06-10)
During infection, nicotinamide adenine dinucleotide phosphate-oxidase of innate immune cells generates important microbicidal reactive oxygen species (ROS) such as hypochlorous acid (HOCl) to kill the invading pathogens. However, excess amounts of HOCl induce oxidative damage of functional biomolecules such as
M B Betancor et al.
Fish physiology and biochemistry, 41(3), 705-720 (2015-03-10)
In vertebrates, selenium (Se) is an essential micronutrient for vertebrates that is involved in antioxidant protection and thyroid hormone regulation among other roles and functions through its incorporation into proteins, the selenoproteins. Long-chain polyunsaturated fatty acids, such as docosahexaenoic acid
Elżbieta Studzińska-Sroka et al.
Antioxidants (Basel, Switzerland), 11(10) (2022-10-28)
Lichens are a source of various biologically active compounds. However, the knowledge about them is still scarce, and their use in medicine is limited. This study aimed to investigate the therapeutic potential of the lichen Platismatia glauca and its major
Alice B Nongonierma et al.
Food chemistry, 141(1), 644-653 (2013-06-19)
Xanthine oxidase (XO) and dipeptidyl peptidase IV (DPP-IV) inhibition by amino acids and dipeptides was studied. Trp and Trp-containing dipeptides (Arg-Trp, Trp-Val, Val-Trp, Lys-Trp and Ile-Trp) inhibited XO. Three amino acids (Met, Leu and Trp) and eight dipeptides (Phe-Leu, Trp-Val
商品
Instructions for working with enzymes supplied as ammonium sulfate suspensions
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