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生物源
microbial
synthetic
品質等級
形狀
liquid
濃度
~0.1 M in ethanol (T)
密度
0.797 g/mL at 20 °C
儲存溫度
2-8°C
SMILES 字串
FS(=O)(=O)Cc1ccccc1
InChI
1S/C7H7FO2S/c8-11(9,10)6-7-4-2-1-3-5-7/h1-5H,6H2
InChI 密鑰
YBYRMVIVWMBXKQ-UHFFFAOYSA-N
應用
苯甲基磺酰氟溶液被用作乳腺癌细胞系、纤维肉瘤细胞系和D5后脑和脊髓神经祖细胞的细胞裂解物缓冲液的组分。
生化/生理作用
施用PMSF可产生与其抗胆碱酯酶作用无关的镇痛作用,并延长中枢给药的β-内啡肽的镇痛作用。
苯甲基磺酰氟(PMSF)是丝氨酸蛋白酶抑制剂。它与蛋白酶的活性位点残基共价结合,抑制蛋白水解活性。PMSF可用在蛋白纯化过程中的细胞裂解物缓冲液中,防止靶蛋白降解。PMSF可有效抑制纳洛酮促发的戒断跳跃。
訊號詞
Danger
危險聲明
危險分類
Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2
儲存類別代碼
3 - Flammable liquids
水污染物質分類(WGK)
WGK 2
閃點(°F)
53.6 °F - closed cup
閃點(°C)
12 °C - closed cup
個人防護裝備
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
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Intraperitoneal (IP) injection of the serine proteinase inhibitor phenylmethylsulfonyl fluoride (PMSF) produced dose-dependent analgesia in Sprague-Dawley rats. AD50 was 2.9 +/- 1.4 (S.E.) mg kg-1, the analgesia was antagonized by naloxone but unaffected by atropine. PMSF significantly enhanced the analgesic
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