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Merck
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46393

Sigma-Aldrich

Fluo-3

suitable for fluorescence, ~70%

别名:

4-(2,7-二氯-6-羟基-3-氧代-9-二苯基)-4′-甲基-2,2′-(亚乙二氧基)二苯胺-N,N,N′,N′-四乙酸

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About This Item

经验公式（希尔记法）:
C36H30Cl2N2O13
CAS号:
123632-39-3
分子量:
769.54
MDL號碼:
MFCD00083337
分類程式碼代碼:
12352106
PubChem物質ID:
329757162
NACRES:
NA.32

化驗

~70%

形狀

solid

溶解度

H2O: soluble

螢光

λex 506 nm; λem 526 nm in 0.1 M Tris pH 8.0, esterase 30 mM Ca2+

適合性

suitable for fluorescence

儲存溫度

−20°C

SMILES 字串

Cc1ccc(N(CC(O)=O)CC(O)=O)c(OCCOc2cc(ccc2N(CC(O)=O)CC(O)=O)C3=C4C=C(Cl)C(=O)C=C4Oc5cc(O)c(Cl)cc35)c1

InChI

1S/C36H30Cl2N2O13/c1-18-2-4-24(39(14-32(43)44)15-33(45)46)30(8-18)51-6-7-52-31-9-19(3-5-25(31)40(16-34(47)48)17-35(49)50)36-20-10-22(37)26(41)12-28(20)53-29-13-27(42)23(38)11-21(29)36/h2-5,8-13,41H,6-7,14-17H2,1H3,(H,43,44)(H,45,46)(H,47,48)(H,49,50)

InChI 密鑰

OZLGRUXZXMRXGP-UHFFFAOYSA-N

應用

Fluo-3和相关分子Fluo3/AM可用作细胞内钙离子（Ca2+）的荧光指示剂。Fluo-3可用于流式细胞术以及使用可见光激发的共焦激光扫描显微术（与在488nm下操作的氩激光源兼容）。与钙结合后，荧光强度增加约40倍。

其他說明

用于流式细胞术的钙离子荧光指示剂。与钙结合后，荧光强度增加约40倍

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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Susanne Staehlke et al.
Cell & bioscience, 8, 22-22 (2018-03-29)
Biomaterial modifications-chemical and topographical-are of particular importance for the integration of materials in biosystems. Cells are known to sense these biomaterial characteristics, but it has remained unclear which physiological processes bio modifications trigger. Hence, the question arises of whether the
P A Vandenberghe et al.
Journal of immunological methods, 127(2), 197-205 (1990-03-09)
Cytoplasmic free calcium [( Ca2+]i) is a key intracellular messenger in many cell types. We have used fluo-3, a recently developed calcium probe, to study [Ca2+]i in resting and stimulated human peripheral blood T lymphocytes. The spectral properties of fluo-3
Qijin Zhao et al.
Cell death and differentiation, 26(9), 1600-1614 (2018-11-06)
Mitochondrial superoxide dismutase 2 (SOD2) is a major antioxidant defense enzyme. Here we provide evidence that SOD2 plays critical roles in maintaining calcium homeostasis in newly generated embryonic cerebral cortical neurons, which is essential for normal mitochondrial function and subcellular
Yi Zheng et al.
Contact dermatitis, 81(3), 184-193 (2019-04-23)
Retinoic acid (RA)-induced dermatitis is the most frequent side-effect limiting its widespread use. However, the exact mechanisms triggering dermatitis are not fully understood, including the role of skin mast cells. The newly discovered Mas-related G-protein-coupled receptor-X2 (MRGPRX2) in mast cells
A Minta et al.
The Journal of biological chemistry, 264(14), 8171-8178 (1989-05-15)
A new group of fluorescent indicators with visible excitation and emission wavelengths has been synthesized for measurements of cytosolic free Ca2+. The five compounds, "rhod-1," "rhod-2," "fluo-1," "fluo-2," and "fluo-3" (Figs. 2 and 3), combine the 8-coordinate tetracarboxylate chelating site
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