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等級
certified reference material
pharmaceutical secondary standard
品質等級
agency
traceable to Ph. Eur. M0300000
traceable to USP 1381006
API 家族
menadione
CofA
current certificate can be downloaded
技術
HPLC: suitable
gas chromatography (GC): suitable
mp
105-107 °C (lit.)
應用
pharmaceutical (small molecule)
形式
neat
儲存溫度
2-8°C
SMILES 字串
CC1=CC(=O)c2ccccc2C1=O
InChI
1S/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H3
InChI 密鑰
MJVAVZPDRWSRRC-UHFFFAOYSA-N
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一般說明
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Menadione is an antihemorrhagic compound and it finds application in blood clotting and bone metabolism as an essential cofactor. Additionally, at relatively higher dose, menadione exhibits antitumor activity on several human cancer cells.
Menadione is an antihemorrhagic compound and it finds application in blood clotting and bone metabolism as an essential cofactor. Additionally, at relatively higher dose, menadione exhibits antitumor activity on several human cancer cells.
應用
Menadione may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography and spectrophotometric methods.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
分析報告
These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.
其他說明
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
腳註
To see an example of a Certificate of Analysis for this material enter LRAA2475 in the slot below. This is an example certificate only and may not be the lot that you receive.
推薦產品
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
訊號詞
Warning
危險分類
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
GC-FID and HPLC-DAD methods for the determination of menadione sodium bisulphite directly and by converting menadione sodium bisulphite to menadione in pharmaceutical preparation
Demirkaya-Miloglu F, et al.
Iranian Journal of Pharmaceutical Research : IJPR, 13(2), 353-353 (2014)
Determination by converting Menadione sodium bisulphite to Menadione in pharmaceutical preparation by two derivative spectrophotometric methods
Demirkaya-Miloglu F, et al.
European International Journal of Science and Technology, 2(2), 89-96 (2013)
Signaling effects of menadione: from tyrosine phosphatase inactivation to connexin phosphorylation.
Kotb Abdelmohsen et al.
Methods in enzymology, 378, 258-272 (2004-03-25)
Renqiong Chen et al.
Microbes and infection, 16(5), 401-408 (2014-03-04)
Penicillium marneffei (P. marneffei) is a human pathogen which persists in macrophages and threatens the immunocompromised patients. To elucidate the mechanisms involved, we investigated the role of extracellular signal-regulated kinases 1 and 2 (ERK1/2) and p38 mitogen-activated protein kinase (p38)
Vera Pader et al.
Infection and immunity, 82(10), 4337-4347 (2014-08-06)
Staphylococcus aureus is responsible for numerous chronic and recurrent infections, which are frequently associated with the emergence of small-colony variants (SCVs) that lack a functional electron transport chain. SCVs exhibit enhanced expression of fibronectin-binding protein (FnBP) and greatly reduced hemolysin
实验方案
Separation of (±)-α-Tocopherol, analytical standard; Menadione (K3), analytical standard; (+)-γ-Tocopherol, analytical standard; Cholecalciferol (D3), analytical standard
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