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product name
Canine MDR1 Knockout, Human BCRP/OATP2B1 double Knockin MDCKII Cells,
生物源
canine kidney (cocker spaniel)
形狀
liquid
運輸包裝
dry ice
儲存溫度
−196°C
基因資訊
human ... ABCG2(9429)
一般說明
MDCK II - Madin-Darby canine kidney- is a subclone derived from the heterogenous The canine MDR1 (cP-gp) efflux transporter gene has been effectively disrupted in both alleles. There is no expression of the cP-gp. Human BCRP and Human OATP2B1 has been transfected into the MDCKII cell line. Validation studies have shown BCRP dependent efflux of estrone-3 sulfate (requires OATP2B1) and teriflunomide (does not require OATP2B1).
特點和優勢
MDCK II - Madin-Darby canine kidney- is a subclone derived from the heterogenous parent line - MDCK (ECACC catalogue no. 85011435) MDCK II cells, which predominate in later passages from MDCK, are reported to display electrical resistance of 100 ohm/cm2. This strain is thought to be derived from the distal tubule or collecting duct of the nephron. The cell line can be used as an experimental model to study the generation and maintenance of cell surface polarity in epithelial cells.
品質
Tested for Mycoplasma, sterility, post-freeze viability, short terminal repeat (STR) analysis for cell line identification.
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
商品
Madin-Darby Canine Kidney (MDCK) cells are one of the most widely used cell lines for a variety of research applications, including drug permeability and transporter studies.
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