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Merck

C5548

Sigma-Aldrich

丁酸氯倍他松

≥98% purity, powder

别名:

21-Chloro-9-fluoro-17-hydroxy-16-methylpregna-1,4-diene-3,11,20-trione 17-butyrate

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About This Item

经验公式(希尔记法):
C26H32ClFO5
CAS号:
分子量:
478.98
EC號碼:
MDL號碼:
分類程式碼代碼:
12171500
PubChem物質ID:
NACRES:
NA.47

product name

丁酸氯倍他松, ≥98%

品質等級

化驗

≥98%

形狀

powder

顏色

white to faint yellow cast

mp

90-100 °C

溶解度

chloroform: 50 mg/mL, clear, faintly yellow

&epsilon ;(消光係數)

13.4 at 243 nm in chloroform

應用

diagnostic assay manufacturing
hematology
histology

儲存溫度

room temp

SMILES 字串

CCCC(=O)O[C@@]1([C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)C(=O)C[C@]12C)C(=O)CCl

InChI

1S/C26H32ClFO5/c1-5-6-22(32)33-26(21(31)14-27)15(2)11-19-18-8-7-16-12-17(29)9-10-23(16,3)25(18,28)20(30)13-24(19,26)4/h9-10,12,15,18-19H,5-8,11,13-14H2,1-4H3/t15-,18-,19-,23-,24-,25-,26-/m0/s1

InChI 密鑰

FBRAWBYQGRLCEK-AVVSTMBFSA-N

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一般說明

Clobetasone butyrate is a corticosteroid.

應用

Clobetasone butyrate has been used as an internal standard for the quantitative assay of clobetasol propionate.
Clobetasone butyrate has been used to analyze its bio-concentration factor (BCF) in Cyprinus carpio.

生化/生理作用

Clobetasone butyrate is a potent topical corticosteroid and is primarily used to treat atopic dermatitis (AD). Low dosage of this drug is used to treat dry eye in Sjogrens syndrome.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges


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分析证书(COA)

Lot/Batch Number

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访问文档库

Liquid chromatography--tandem mass spectrometric assay for clobetasol propionate in human serum from patients with atopic dermatitis
Sparidans RW, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 878(23), 2150-2154 (2010)
Uptake and biological effects of synthetic glucocorticoids in common carp (Cyprinus carpio)
Nakayama K, et al.
Marine Pollution Bulletin, 85(2), 370-375 (2014)
Fluticasone propionate 0.05% cream once daily versus clobetasone butyrate 0.05% cream twice daily in children with atopic dermatitis
Wolkerstorfer A, et al.
Journal of the American Academy of Dermatology, 39(2), 226-231 (1998)
Community Pharmacy - E-Book: Symptoms Diagnosis and Treatment (2011)
Safety and efficacy of 0.1% clobetasone butyrate eyedrops in the treatment of dry eye in Sjogren syndrome
Aragona P, et al.
European Journal of Ophthalmology, 23(3) (2013)

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