推荐产品
生物源
goat
品質等級
共軛
peroxidase conjugate
抗體表格
F(ab′)2 fragment of affinity isolated antibody
抗體產品種類
secondary antibodies
無性繁殖
polyclonal
物種活性
mouse
製造商／商標名
Chemicon®
濃度
0.8 mg/mL
技術
ELISA: suitable
western blot: suitable
運輸包裝
wet ice
目標翻譯後修改
unmodified
一般說明
免疫球蛋白G（IgG）是人血清中最丰富的免疫球蛋白。IgM 占到了总血清免疫球蛋白的5-10%。这些免疫球蛋白包含四条多肽链，包括两条重链（H）和两条轻链（L）。这些多肽链通过二硫键相互连接。IgM是脊椎动物中高度保守的抗体。IgM以五聚体的形式存在。IgG和IgM都由B细胞分泌。
應用
山羊抗小鼠IgG& IgM抗体（HRP偶联物）已用于蛋白质印迹（1：400）和免疫荧光（1：500）。
生化／生理作用
IgG促进细胞介导的抗体依赖性细胞毒性（ADCC）。它还有助于激活补体系统的经典途径。IgG 中和病毒颗粒和毒素。IgM是在免疫应答早期表达的抗体，它有助于吞噬凋亡细胞。它具有多反应和自动反应功能。IgM通过介导组织基分子的清除，诱导组织稳态。较低的血清IgM水平与增强的自身免疫反应和较高的感染风险有关。
法律資訊
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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儲存類別代碼
13 - Non Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Hongsheng Wang et al.
Frontiers in immunology, 7, 99-99 (2016-03-26)
Most natural IgM antibodies are encoded by germline Ig sequences and are produced in large quantities by both mice and humans in the absence of intentional immunization. Natural IgM are reactive with many conserved epitopes, including those shared by microorganisms
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