推荐产品
生物源
human
品質等級
化驗
≤95% (SDS-PAGE)
形狀
liquid
製造商／商標名
Chemicon®
濃度
0.276 mg/mL
NCBI登錄號
UniProt登錄號
一般說明
Apolipoprotein E (Apo E) is a multifunctional protein and exists in 3 isoforms namely apoE2, apoE3, and apoE4. It is the constituent of plasma lipoproteins. Apo E is produced by various tissues and is majorly found in interstitial fluid and lymph. It is released in a lipid-poor form.
應用
Apolipoprotein E, human has been used as a standard for the quantification of ApoE protein in the sucrose density gradient (SDG) fractions and the unfractionated brain homogenates using an in-house developed sandwich enzyme-linked immunosorbent assay (ELISA). It has also been used in western blotting to assess its exogenous effects on low-density lipoprotein (LDL)-heparin interactions.
生化／生理作用
Apolipoprotein E (Apo E) serves as a ligand for low-density receptors and participates in the transport and redistribution of cholesterol and other lipids. It is thought to be involved in tissue repair as increased amounts of the protein are found at sites or peripheral nerve injury and regeneration. A mutant form is associated with type III hyperlipoproteinemia. Apo E plays a crucial role in neurobiology and neurodegenerative diseases.
外觀
Liquid in 10 mM NH4HCO3, pH 8.0.
法律資訊
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Yadong Huang et al.
Neurobiology of disease, 72 Pt A, 3-12 (2014-09-01)
Apolipoprotein (apo) E is a multifunctional protein with central roles in lipid metabolism, neurobiology, and neurodegenerative diseases. It has three major isoforms (apoE2, apoE3, and apoE4) with different effects on lipid and neuronal homeostasis. A major function of apoE is
Paul S Hauser et al.
Progress in lipid research, 50(1), 62-74 (2010-09-22)
Apolipoprotein (apo) E has a storied history as a lipid transport protein. The integral association between cholesterol homeostasis and lipoprotein clearance from circulation are intimately related to apoE's function as a ligand for cell-surface receptors of the low-density lipoprotein receptor
Zaili Yang et al.
Journal of virology, 90(21), 9632-9643 (2016-08-19)
Hepatitis C virus (HCV) is a major cause of chronic liver disease, infecting approximately 170 million people worldwide. HCV assembly is tightly associated with the lipoprotein pathway. Exchangeable apolipoprotein E (apoE) is incorporated on infectious HCV virions and is important
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