推荐产品
生物源
rabbit
品質等級
抗體表格
serum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
物種活性
mouse, human, rat
技術
immunoprecipitation (IP): suitable
western blot: suitable
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... XRCC1(7515)
一般說明
DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. XRCC1 interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells.
免疫原
Linear peptide corresponding to mouse Xrcc1.
應用
Anti-Xrcc1 Antibody is a highly specific rabbit polyclonal antibody, that targets XRCC1 & has been tested in western blotting & IP.
Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected Xrcc1 in HepG2 cell lysate.
Western Blotting Analysis: A representative lot from an independent laboratory detected Xrcc1 in HEK293T, HeLa and MEF cell lysates (Lee, Y., et al. (2009). Nature Neurosci. 12:(8):973-980.).
Immunoprecipitation Analysis: A representative lot from an independent laboratory detected Xrcc1 in HEK293T, HeLa and MEF cell lysates (Lee, Y., et al. (2009). Nature Neurosci. 12:(8):973-980.).
Western Blotting Analysis: A representative lot from an independent laboratory detected Xrcc1 in HEK293T, HeLa and MEF cell lysates (Lee, Y., et al. (2009). Nature Neurosci. 12:(8):973-980.).
Immunoprecipitation Analysis: A representative lot from an independent laboratory detected Xrcc1 in HEK293T, HeLa and MEF cell lysates (Lee, Y., et al. (2009). Nature Neurosci. 12:(8):973-980.).
品質
Evaluated by Western Blotting in Jurkat cell lysate.
Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected Xrcc1 in 10 µg of Jurkat cell lysate.
Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected Xrcc1 in 10 µg of Jurkat cell lysate.
標靶描述
~80 kDa observed. The molecular weight of this protein is calculated at 69 kDa; however it has been observed at ~80 kDa (Lee, Y., et al. (2009). Nature Neurosci. 12:(8):973-980.). An uncharacterized band may be observed at ~51 kDa in some cell lysates.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
Youngsoo Lee et al.
Nature neuroscience, 12(8), 973-980 (2009-07-28)
Defective responses to DNA single strand breaks underlie various neurodegenerative diseases. However, the exact role of this repair pathway during the development and maintenance of the nervous system is unclear. Using murine neural-specific inactivation of Xrcc1, a factor that is
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