566327

SIRT1/2 Inhibitor VII

The SIRT1/2 Inhibitor VII, also referenced under CAS 143034-06-4, controls the biological activity of SIRT1/2. This small molecule/inhibitor is primarily used for Cell Structure applications.

• 别名: SIRT1/2 Inhibitor VII, 5-(2-Naphthylidine)-2-thiobarbituric acid, SIRT1 Inhibitor V, SIRT2 Inhibitor VII
• 经验公式（希尔记法）: C₁₅H₁₀N₂O₂S
• CAS号: 143034-06-4
• 分子量: 282.32
• 分類程式碼代碼: 12352200

属性

• 品質等級: 100
• 化驗: ≥95% (NMR)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: white to off-white
• 溶解度: DMSO: 3 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C

说明

一般說明

A thiobarbiturate compound that acts as an inhibitor against sirtuins (IC₅₀ = 13.2 & 9.1 µM using human SIRT1 & SIRT2, respectively), the NAD⁺-dependent class III histone deacetylases (HDACs). Computer-aided molecular structural anaylsis reveals that both hydrogen bonds and van der Waals type of interactions contribute to the successful docking of the inhibitor into the nicotinamde subpocket of SIRT2 with the bulky naphthyl group being placed directly into the acetyllysine substrate channel.

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Uciechowska, U., et al. 2008. ChemMedChem3, 1965.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable