推荐产品
品質等級
化驗
≥98% (HPLC)
形狀
solid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
desiccated
雜質
≤10 EU/mg Endotoxin (dry weight)
顏色
white to off-white
溶解度
methanol: 20 mg/mL
water: 50 mg/mL
運輸包裝
ambient
儲存溫度
−20°C
InChI
1S/C22H29N7O5.2ClH/c1-28(2)19-17-20(25-10-24-19)29(11-26-17)22-18(31)16(15(9-30)34-22)27-21(32)14(23)8-12-4-6-13(33-3)7-5-12;;/h4-7,10-11,14-16,18,22,30-31H,8-9,23H2,1-3H3,(H,27,32);2*1H/t14-,15+,16?,18+,22+;;/m0../s1
InChI 密鑰
MKSVFGKWZLUTTO-USYAMCSGSA-N
一般說明
一种氨基核苷类抗生素，可作为原核和真核蛋白质合成抑制剂。类似于氨酰tRNA的氨酰腺苷酸末端，竞争与大核糖体亚单位的“A位点”结合。其掺入生长中的多肽，导致链延伸终止和新生多肽基嘌呤霉素的释放。用于选择表达转染pac基因（白链霉菌）的哺乳动物细胞系，其产物嘌呤霉素乙酰转移酶通过乙酰化使药物失活。诱导胸腺细胞和HL-60白血病细胞内DNA断裂。转染哺乳动物细胞的推荐选择范围为1至30 µg/ml。
嘌呤霉素，CAS 58-58-2，是一种蛋白质合成抑制剂，可导致新生多肽链过早释放。
蛋白质合成抑制剂。通过导致新生多肽链过早释放来抑制翻译。诱导胸腺细胞和HL-60白血病细胞内DNA断裂。
生化／生理作用
首要靶标
蛋白质合成
蛋白质合成
警告
毒性：有害（C）
重構
复溶后，通过0.22 µm孔径的过滤器过滤灭菌，等分并冷冻（-20°C）。贮备溶液在-20°C下可稳定保存至多3个月。
其他說明
Chow, S.C., et al. 1995.Exp.Cell Res.216, 149.
Kaufman, S.H., et al. 1993.Cancer Res.53, 3976.
de la Luna, S. and Ortín, J. 1992.Methods Enzymol.216, 376.
Chow, S.C., et al. 1991.Exp.Cell Res. 216, 149.
Kaufman, S.H., et al. 1993.Cancer Res.53, 3976.
de la Luna, S. and Ortín, J. 1992.Methods Enzymol.216, 376.
Chow, S.C., et al. 1991.Exp.Cell Res. 216, 149.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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