506132

Pifithrin-α

≥95% (HPLC), solid, p53 inhibitor, Calbiochem^®

• 别名: Pifithrin-α, 2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1- p-tolylethanone, HBr
• 经验公式（希尔记法）: C₁₆H₁₈N₂OS · xHBr
• CAS号: 63208-82-2
• 分子量: 286.39 (free base basis)
• MDL號碼: MFCD00417851
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• product name: Pifithrin-α, A cell-permeable chemical inhibitor of p53.
• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: off-white
• 溶解度: DMSO: 100 mg/mL
• 運輸包裝: ambient
• 儲存溫度: −20°C
• InChI: 1S/C16H18N2OS.BrH/c1-11-6-8-12(9-7-11)14(19)10-18-13-4-2-3-5-15(13)20-16(18)17;/h6-9,17H,2-5,10H2,1H3;1H
• InChI 密鑰: HAGVCKULCLQGRF-UHFFFAOYSA-N

说明

一般說明

A cell-permeable chemical inhibitor of p53. Reversibly inhibits p53-dependent transactivation of p53-responsive genes and reversibly blocks p53-mediated apoptosis. Inhibits p53-dependent growth arrest of human diploid fibroblasts in response to DNA damage but has no effect on p53-deficient fibroblasts. Protects normal tissues from the deleterious side effects of chemotherapy. Has been reported to protect neurons against β-amyloid peptide and glutamate-induced apoptosis.

A reversible inhibitor of p53-dependent transactivation of p53-responsive genes and reversibly blocks p53-mediated apoptosis. Inhibits p53-dependent growth arrest of human diploid fibroblasts in response to DNA damage but has no effect on p53-deficient fibroblasts. Protects mice from lethal genotoxic stress associated with anticancer treatment without promoting tumor formation. Has been reported to protect neurons against β-amyloid and glutamate-induced apoptosis.

生化／生理作用

Cell permeable: yes

Primary Target
PS3

Product does not compete with ATP.

Reversible: yes

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot into cold tubes and freeze (-20°C). Stock solutions in DMSO are stable for 3 months at -20°C. Unstable in aqueous solutions.

其他說明

Murphy, P.J.M., et al. 2004. J. Biol. Chem.279, 30195.
Culmsee, C., et al. 2001. J. Neurochem.77, 220.
Komarova, E.A., and Gudkov, A.V. 2000. Biochemistry (Mosc.) 65, 41.
Stadler, P., et al. 2000. Strahlenther Onkol. 176, 98.
Ferber, D. 1999. Science 285, 1651.
Jacquemin-Sablon, A. 1999. Bull. Cancer86, 894.
Komarov, P.G., et al. 1999. Science 285, 1733.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable