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品質等級
化驗
≥98% (HPLC)
形狀
solid
儲存條件
desiccated
溶解度
DMSO: 20 mg/mL
運輸包裝
dry ice
儲存溫度
−20°C
SMILES 字串
Br[H].Cc1ccc(cc1)-c2cn3c4CCCCc4sc3n2
InChI
1S/C16H16N2S.BrH/c1-11-6-8-12(9-7-11)13-10-18-14-4-2-3-5-15(14)19-16(18)17-13;/h6-10H,2-5H2,1H3;1H
InChI 密鑰
SGNCOAOESGSEOP-UHFFFAOYSA-N
應用
Cyclic Pifithrin-α hydrobromide has been used as p53 inhibitor to study its role in cigarette smoke−induced apoptosis of pulmonary endothelial cells.
生化/生理作用
A stable analog of Pifithrin-α (Product Code P4359) with similar biological activities and lower cellular toxicity.
包裝
Protect from light.
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation
The Journal of Biological Chemistry, 279(29), 30195-30201 (2004)
p53 mediates cigarette smoke-induced apoptosis of pulmonary endothelial cells: inhibitory effects of macrophage migration inhibitor factor
American Journal of Respiratory Cell and Molecular Biology, 44(3), 323-332 (2011)
American journal of respiratory cell and molecular biology, 44(3), 323-332 (2010-05-08)
Exposure to cigarette smoke (CS) is the most common cause of emphysema, a debilitating pulmonary disease histopathologically characterized by the irreversible destruction of lung architecture. Mounting evidence links enhanced endothelial apoptosis causally to the development of emphysema. However, the molecular
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