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Merck
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主要文件

506101

Sigma-Aldrich

p21-Activated Kinase Inhibitor, PAK18

The p21-Activated Kinase Inhibitor, PAK18 controls the biological activity of p21-Activated Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

别名:

p21-Activated Kinase Inhibitor, PAK18, H₂N-RKKRRQRRR~G~PPVIAPRPEHTKSVYTRS-CO₂H, PAK Inhibitor I

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About This Item

经验公式(希尔记法):
C146H254N58O37
分子量:
3413.95
分類程式碼代碼:
12352200

品質等級

化驗

≥97% (HPLC)

形狀

lyophilized

製造商/商標名

Calbiochem®

儲存條件

OK to freeze
desiccated (hygroscopic)
protect from light

溶解度

water: 1 mg/mL
DMSO: 5 mg/mL

運輸包裝

ambient

儲存溫度

−20°C

一般說明

A PAK (p21-activated kinase) inhibitor peptide that is composed of the cell permeant TAT peptide sequence and an 18-mer Pro-rich PIX-interacting motif of PAK that disrupts PIX-PAK interaction, reduces cellular PAK phosphorylation, and induces neurodegenerative morphology in hippocampal neurons in vitro. Intracerebroventricular administration of PAK18 in mice resulted in Alzheimer-like disease phenotype in vivo. PIX-interacting motif sequence has also been shown to block ras-dependent tumor growth and PAK activation in NIH-3T3 cells. The inactive control peptide, PAK18-R192A, is also available (Cat. No. 506102).

生化/生理作用

Cell permeable: no
Primary Target
PAK (p21-activated kinase)
Product does not compete with ATP.
Reversible: no

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

序列

H-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg~Gly~Pro-Pro-Val-Ile-Ala-Pro-Arg-Pro-Glu-His-Thr-Lys-Ser-Val-Tyr-Thr-Arg-Ser-OH

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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