推荐产品
化驗
≥99% (HPLC)
品質等級
形狀
solid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
protect from light
顏色
white
溶解度
water: 100 mM
儲存溫度
2-8°C
InChI
1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7)
InChI 密鑰
ZJQHPWUVQPJPQT-UHFFFAOYSA-N
一般說明
一种蘑菇毒蝇伞的成分和精神活性成分，作为GABAA 受体的有效激动剂（新生大鼠和成年大鼠的EC50分别为28 µM和33 µM），对高亲和力受体亚型具有优先功效和选择性。研究表明可渗透血脑屏障。损害联想和记忆功能。
生化／生理作用
主要靶标
GABAA
GABAA
警告
毒性：有毒（F）
重構
复溶后，等分并冷冻保存（-20°C）。贮备液在-20°C下可稳定保存至多3个月。
其他說明
Chandra, D., et al. 2010.Neuropsychopharmacology.35, 999.
Fischer, H., et al. 2005.J. Physiol.564, 465.
Ramirez, D.R., et al. 2005.Neurobiol.Learning and Memory.84, 184.
Fischer, H., et al. 2005.J. Physiol.564, 465.
Ramirez, D.R., et al. 2005.Neurobiol.Learning and Memory.84, 184.
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法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 2 Oral - STOT SE 3
標靶器官
Central nervous system
儲存類別代碼
6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Donna R Ramirez et al.
Neurobiology of learning and memory, 84(3), 184-191 (2005-08-10)
A matching-to-position (MTP) paradigm was altered to influence the type of associations a rat would use to solve the task. Our main behavioral manipulation was the application of the differential outcomes procedure (DOP). The DOP involves correlating each to-be-remembered event
Dev Chandra et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 35(4), 999-1007 (2009-12-25)
Muscimol has been regarded as a universal agonist for all gamma-aminobutyric acid type A receptor (GABA(A)-R) subtypes. However, brain regional distribution of muscimol's high-affinity binding sites greatly differs from those of other binding sites of the GABA(A)-R. To test whether
Harald Fischer et al.
The Journal of physiology, 564(Pt 2), 465-474 (2005-02-26)
The effects of gamma-aminobutyric acid (GABA) on the electrophysiological properties of intracardiac neurones were investigated in the intracardiac ganglion plexus in situ and in dissociated neurones from neonatal, juvenile and adult rat hearts. Focal application of GABA evoked a depolarizing
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