252750

甲磺酸去铁胺

Iron chelating agent

• 别名: 甲磺酸去铁胺, 甲磺酸去铁胺，DFOM，铁螯合剂II
• 经验公式（希尔记法）: C₂₅H₄₈N₆O₈ · xCH₄O₃S
• CAS号: 138-14-7
• 分子量: 560.68 (free base basis)
• MDL號碼: MFCD00058605
• 分類程式碼代碼: 41116107
• NACRES: NA.25

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 反應適用性: reagent type: chelator
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic)
• 顏色: faint yellow
• 溶解度: water: 50 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• InChI: 1S/C25H48N6O8.CH4O3S/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26;1-5(2,3)4/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34);1H3,(H,2,3,4)
• InChI 密鑰: IDDIJAWJANBQLJ-UHFFFAOYSA-N

说明

一般說明

铁螯合剂。完全预防多巴胺引起的细胞死亡。还干扰羟基自由基的形成，羟基自由基在几种疾病状态中介导组织损伤。显示体外和体内对血管平滑肌细胞的抗增殖作用。还可以通过异羟肟酸部分与反式过氧亚硝酸的反应来抑制过氧亚硝酸盐的氧化化学作用。

應用

• Defective ferritinophagy and imbalanced iron metabolism in PBDE-47-triggered neuronal ferroptosis and salvage by Canolol.: This study explores the application of Deferoxamine Mesylate in mitigating iron overload and oxidative stress in neuronal cells, demonstrating its potential in neuroprotection and treatment strategies for neurodegenerative disorders (Wang et al., 2024).


• Ferroptosis resists intracellular Vibrio splendidus AJ01 mediated by ferroportin in sea cucumber Apostichopus japonicus.: The study demonstrates the potential of Deferoxamine Mesylate in aquatic animal health, particularly in enhancing the resistance against bacterial infections by modulating ferroptosis pathways (Wang et al., 2024).

警告

毒性：有害 & 致癌/致畸性（E）

其他說明

Bergeron, R.J., et al. 1996.J. Med. Chem. 39, 1575.
Ben-Shachar, D., et al. 1995.J. Neurochem.64, 718.
Denicola, A., et al. 1995.Free Radic.Biol. Med. 19, 11.
Dzwigaj, S., and pererat, H., 1995.Free Radic.Res.14, 103.
Dang, S., et al. 1994.Res. Commun.Mol.Pathol.Pharmacol.86, 43.
Porreca, E., et al. 1994.Arterioscler.Thromb.14, 299.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable