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一般說明
The TGF-β signalling cascade regulates diverse cellular processes, including cell proliferation, differentiation, apoptosis, adhesion and migration. It plays a fundamental role in a number of different physiological and pathological processes, such as embryonic development, adult homoeostasis, tumourigenesis and tissue fibrogenesis. Smad7 has been identified as a key negative regulator of TGF-β signalling, antagonising it through multiple mechanisms in both the cytoplasm and in the nucleus. Altered expression of Smad7 is often associated with human diseases, such as cancer, tissue fibrosis and inflammatory diseases.
應用
Ubiquitination Cascade Comoponent: Substrate
外觀
Purified using immobilized metal affinity chromatography.
法律資訊
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
訊號詞
Warning
危險聲明
危險分類
Skin Sens. 1
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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