SML1762

SI-2

≥98% (HPLC)

• 别名: (1E)-1-(2-Pyridinyl)ethanone 1-(1-methyl-1H-benzoimidazol-2-yl)-hydrazone, (1E)-N-(1-Methyl-1H-benzoimidazol-2-yl)-N′-(1-pyridin-2-yl-ethylidene)-hydrazine
• 经验公式（希尔记法）: C₁₅H₁₅N₅
• CAS号: 380537-35-9
• 分子量: 265.31
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: , light yellow to dark orange
• 溶解度: DMSO: 20 mg/mL, clear
• 儲存溫度: 2-8°C
• SMILES 字串: C/C(C1=CC=CC=N1)=N\NC2=NC3=C(C=CC=C3)N2C

说明

生化／生理作用

SI-2 targets the receptor-interacting domain (RID) of steroid receptor coactivators (SRCs) and suppresses cellular transcriptional activity (Effec. conc. >/= 5 nM in cell-based SRC-1, SRC-2, and SRC-3 reporter assays) by downregulating SRCs protein, but not transcript level (Effec. conc. >/= 12.5 nM against SRC-3, >/= 25 nM against SRC-1 and SCR-2 in MDA-MB-468 culture). SI-2 is cytotoxic to breast cancer cultures (IC₅₀ = 1.5 nM/BT-474, 3.4 nM/MDA-MB-468, 22 nM/MCF-7), but not to normal hepatocytes even at 500 nM concentration. SI-2 is reported to be orally available in mice and, when administered intraperitoneally (2 mg/kg b.i.d.), effectively suppress MDA-MB-468-derived tumor expansion in mice in vivowith good pharmacokinetics (C_max = 30 μM, t_max = 0.25 h, t_1/2 = 1.0 h; 20 mg/kg i.p.) and no apparent adverse effects to the animals.

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H315,H319
• 防範說明: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• 危險分類: Eye Irrit. 2 - Skin Irrit. 2
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable