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Merck
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Key Documents

14-378

Sigma-Aldrich

MKK4/SKK1 Protein, inactive, 50 g

Unactive, recombinant mouse MKK4, corresponding to amino acids 35-397, fused to an N-terminal GST-tag, for use in Kinase Assays.

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About This Item

分類程式碼代碼:
12352200
eCl@ss:
32160405
NACRES:
NA.32

生物源

mouse

品質等級

100

重組細胞

expressed in E. coli

分子量

Mw 65 kDa

製造商／商標名

Upstate®

技術

activity assay: suitable (kinase)

NCBI登錄號

NM_003010.2

UniProt登錄號

P45985

運輸包裝

dry ice

基因資訊

mouse ... MAP2K4(26398)

一般說明

Product Source: expressed in E. coli
Recombinant mouse MKK4, corresponding to amino acids 35-397, fused to an Nterminal GST-tag

生化／生理作用

Protein Target: MKK4
Target Sub-Family: STE

品質

routinely evaluated by phosphorylation of ATF2 substrate

外觀

GSH-agarose chromatography

儲存和穩定性

6 months at -20C

其他說明

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

法律資訊

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H317

危險分類

Skin Sens. 1

儲存類別代碼

10 - Combustible liquids

水污染物質分類（WGK）

WGK 1

分析证书(COA)

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Eleanore A Gross et al.
The Journal of biological chemistry, 277(16), 13873-13882 (2002-02-12)
Mitogen-activated protein (MAP) kinase pathways are three-kinase modules that mediate diverse cellular processes and have been highly conserved among eukaryotes. By using a functional complementation screen in yeast, we have identified a human MAP kinase kinase kinase (MAPKKK) that shares
Luis Cedeno-Rosario et al.
The Journal of biological chemistry, 298(8), 102263-102263 (2022-07-18)
Mixed lineage kinase 3 (MLK3) is a serine/threonine mitogen-activated protein kinase kinase kinase that promotes the activation of multiple mitogen-activated protein kinase pathways and is required for invasion and proliferation of ovarian cancer cells. Inhibition of MLK activity causes G2/M

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