推荐产品
形狀
powder
包裝
pkg of 1 × 5 mg (860576P-5mg)
製造商／商標名
Avanti Research™ - A Croda Brand 860576P
脂質類型
sphingolipids
運輸包裝
dry ice
儲存溫度
−20°C
SMILES 字串
[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCCCCCCCCCC)=O)CO[C@H](O1)[C@H](O)[C@@H](O)[C@@H]([C@H]1CO)O[C@H](O2)[C@H](O)[C@@H](O)[C@H]([C@H]2CO)O
一般說明
Lactosylceramide (LacCer) is a glycosphingolipid, which is found majorly in the nervous system and myelin sheath. It comprises a hydrophobic ceramide lipid and a hydrophilic sugar moiety.
應用
C16 Lactosyl(β) Ceramide (d18:1/16:0) or D-lactosyl-β-1,1′ N-palmitoyl-D-erythro-sphingosine has been used as a lipid standard in mass spectrometry imaging of lipids in human skin disease model hidradenitis suppurativa. It may be used in the preparation of liposomes.
生化／生理作用
Lactosylceramide (LacCer) is a structural and signaling lipid. It is crucial for signal transduction and cell adhesion. LacCer facilitates microbial attachment and also acts as an adhesion receptor for pathogens. It regulates cellular stress response and apoptosis. LacCer also modulates in cell proliferation and microbial pathogenesis. It is implicated in innate immune responses, host-tissue pathogen interactions and chronic inflammatory diseases.
包裝
5 mL Amber Glass Screw Cap Vial (860576P-5mg)
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
儲存類別代碼
11 - Combustible Solids
Chemistry, Biochemistry, and Biology of 1-3 Beta Glucans and Related Polysaccharide, 191, 106-114 (2009)
Biserka Bakrac et al.
The Journal of biological chemistry, 283(27), 18665-18677 (2008-04-30)
Sphingomyelin (SM) is abundant in the outer leaflet of the cell plasma membrane, with the ability to concentrate in so-called lipid rafts. These specialized cholesterol-rich microdomains not only are associated with many physiological processes but also are exploited as cell
Jarod A Fincher et al.
Scientific reports, 9(1), 17508-17508 (2019-11-27)
Neutral lipids have been implicated in a host of potentially debilitating human diseases, such as heart disease, type-2 diabetes, and metabolic syndrome. Matrix-assisted laser desorption ionization (MALDI), the method-of-choice for mass spectrometry imaging (MSI), has led to remarkable success in
Jamie L Betker et al.
Journal of pharmaceutical sciences (2020-02-01)
Nanoparticle-mediated drug delivery has long utilized PEGylation as a mechanism for reducing uptake by the reticuloendothelial system and extending circulation lifetimes. However, studies over the past 2 decades have established that immune responses to PEG can promote clearance on repeat injection
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