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Merck

860470P

Avanti

1-deoxysphingosine

Avanti Research - A Croda Brand 860470P, powder

别名:

1-deoxysphingosine (m18:1)

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About This Item

经验公式(希尔记法):
C18H37NO
分子量:
283.49
分類程式碼代碼:
12352211
NACRES:
NA.25

形狀

powder

包裝

pkg of 1 × 1 mg (860470P-1mg)
pkg of 1 × 10 mg (860470P-10mg)

製造商/商標名

Avanti Research - A Croda Brand 860470P

脂質類型

bioactive lipids
sphingolipids

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

C[C@@](N)([H])[C@]([H])(O)/C=C/CCCCCCCCCCCCC

一般說明

1-deoxysphingosine (1-deoxySO) has a (4E) double bond in its structure and is synthesized by the catabolism of 1-deoxyceramide in the presence of ceramidase enzyme. It is an unsaturated deoxy-sphingoid base.

應用

1-deoxysphingosine may be used for the complex preparation with bovine serum albumin for cytotoxicity testing of MN9D dopaminergic neuroblastoma cell line and dorsal root ganglion neurons cultures. It may also be used as a standard for quantification of spingolipids from human plasma samples by liquid chromatography electrospray ionization tandem mass spectrometry (LC−ESI−MS/MS).

生化/生理作用

1-deoxysphingosine levels are elevated in lymphoblasts in hereditary sensory neuropathy type 1 (HSAN1) disorder.

包裝

5 mL Amber Glass Screw Cap Vial (860470P-10mg)
5 mL Amber Glass Screw Cap Vial (860470P-1mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3


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Analysis of sphingolipids in extracted human plasma using liquid chromatography electrospray ionization tandem mass spectrometry
Bui HH, et al.
Analytical Biochemistry, 423(2), 187-194 (2012)
Regula Steiner et al.
Journal of lipid research, 57(7), 1194-1203 (2016-05-12)
The 1-deoxysphingolipids (1-deoxySLs) are formed by an alternate substrate usage of the enzyme, serine-palmitoyltransferase, and are devoid of the C1-OH-group present in canonical sphingolipids. Pathologically elevated 1-deoxySL levels are associated with the rare inherited neuropathy, HSAN1, and diabetes type 2
M F Dohrn et al.
European journal of neurology, 22(5), 806-814 (2015-01-28)
Diabetic distal sensorimotor polyneuropathy (DSPN) is a frequent, disabling complication of diabetes mellitus. There is increasing evidence that sphingolipids play a role in insulin resistance and type 2 diabetes (T2DM). Whether neurotoxic 1-deoxy-sphingolipids are elevated in DSPN patients' plasma and
Hereditary sensory neuropathy type 1 is caused by the accumulation of two neurotoxic sphingolipids
Penno A, et al.
The Journal of Biological Chemistry, 285(15), 11178-11187 (2010)
Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons
Martinez TN, et al.
Mol. Neurodegener., 7(1), 45-45 (2012)

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