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Merck

860063P

Avanti

鞘磷脂

Avanti Research - A Croda Brand

别名:

鞘磷脂

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About This Item

分類程式碼代碼:
12352211
NACRES:
NA.25

描述

Sphingomyelin (Milk, Bovine)

化驗

>99% (TLC)

形狀

powder

包裝

pkg of 1 × 200 mg (860063P-200mg)
pkg of 1 × 25 mg (860063P-25mg)

製造商/商標名

Avanti Research - A Croda Brand

脂質類型

sphingolipids

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCCCCCCCCCCCCCCCCC)=O)COP([O-])(OCC[N+](C)(C)C)=O

InChI

1S/C46H93N2O6P/c1-6-8-10-12-14-16-18-20-21-22-23-24-25-26-28-30-32-34-36-38-40-46(50)47-44(43-54-55(51,52)53-42-41-48(3,4)5)45(49)39-37-35-33-31-29-27-19-17-15-13-11-9-7-2/h37,39,44-45,49H,6-36,38,40-43H2,1-5H3,(H-,47,50,51,52)/b39-37+/t44-,45+/m0/s1

InChI 密鑰

SXZWBNWTCVLZJN-NMIJJABPSA-N

一般說明

作为细胞膜的主要成分,鞘磷脂在神经细胞(髓鞘)膜和红细胞膜中的浓度特别高。以前认为,它是因鞘氨醇碱基的2-酰胺基、3-羟基和4,5-反式双键介导的分子间相互作用而具有与磷脂酰胆碱功能相似的纯结构作用。但是,现在人们认识到,鞘磷脂对胆固醇具有高亲和力,这两种脂质在液体无序相中紧密堆积成液体有序结构域,形成脂质筏。这些膜微结构域被认为是调节蛋白质定位和相互作用的信号转导平台。但是,鞘磷脂不仅是会影响信号传导的脂质筏成分,它还是神经酰胺和其他鞘脂代谢(包括鞘磷脂循环或鞘脂网络)产物的前体。
鞘磷脂和相关脂质

應用

Milk SM 已被用作脂质标准品。它也适用于检测粪便中的神经酰胺和差示扫描量热法。

包裝

5 mL棕色玻璃螺旋盖小瓶(860063P-200mg)
5 mL棕色玻璃螺旋盖小瓶(860063P-25mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

儲存類別代碼

11 - Combustible Solids


分析证书(COA)

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The Journal of biological chemistry, 281(11), 7324-7331 (2006)
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