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化驗
>99% (TLC)
形狀
liquid
包裝
pkg of 1 × 1 mL (840030C-10mg)
pkg of 1 × 2.5 mL (840030C-25mg)
製造商/商標名
Avanti Research™ - A Croda Brand 840030C
濃度
10 mg/mL (840030C-10mg)
10 mg/mL (840030C-25mg)
脂質類型
phospholipids
cardiolipins
運輸包裝
dry ice
儲存溫度
−20°C
SMILES 字串
[H][C@@](COP([O-])(OC[C@](C([O-])=O)([H])[NH3+])=O)(OC(CCCCC)=O)COC(CCCCC)=O.[Na+]
InChI
1S/C18H34NO10P.Na/c1-3-5-7-9-16(20)26-11-14(29-17(21)10-8-6-4-2)12-27-30(24,25)28-13-15(19)18(22)23;/h14-15H,3-13,19H2,1-2H3,(H,22,23)(H,24,25);/q;+1/p-1/t14-,15+;/m1./s1
InChI 密鑰
OPDYVXCKOQKYDZ-LIOBNPLQSA-M
一般說明
Phosphoserine/phosphatidylserine (PS) is an endogenous phospholipid, that is found in all polyanionic macromolecules like bone, enamel and dentin.
應用
06:0 PS may be used:
- to study its effect on α-syn (α-synuclein) oligomerization by DA (dopamine)
- to prepare phosphatidylserine (PS) liposomes
- as a phospholipid substrate to determine the kinetic parameters for phospholipase C by chromogenic assay
生化/生理作用
Phosphoserine (PS) can be used as a template moiety for the recognition of cancer antigen 125 (CA 125). It is essential for healthy nerve cell membranes and myelin. Exogenous PS can be actively absorbed in humans and is blood-brain barrier traversable. PS actively participates in the locomotor functions.
包裝
5 mL Clear Glass Sealed Ampule (840030C-10mg)
5 mL Clear Glass Sealed Ampule (840030C-25mg)
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
訊號詞
Danger
危險分類
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
標靶器官
Central nervous system
水污染物質分類(WGK)
WGK 3
The Journal of biological chemistry, 293(32), 12634-12646 (2018-05-26)
Triggering receptor expressed on myeloid cells 2 (TREM2) is an immune receptor expressed on the surface of microglia, macrophages, dendritic cells, and osteoclasts. The R47H TREM2 variant is a significant risk factor for late-onset Alzheimer's disease (AD), and the molecular
Bioscience reports, 33(5) (2013-09-27)
The deposition of α-syn (α-synuclein) as amyloid fibrils and the selective loss of DA (dopamine) containing neurons in the substantia nigra are two key features of PD (Parkinson's disease). α-syn is a natively unfolded protein and adopts an α-helical conformation
Annual review of biophysics, 39, 407-427 (2010-03-03)
Phosphatidylserine (PS) is the most abundant negatively charged phospholipid in eukaryotic membranes. PS directs the binding of proteins that bear C2 or gamma-carboxyglutamic domains and contributes to the electrostatic association of polycationic ligands with cellular membranes. Rather than being evenly
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