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Merck

810602P

Avanti

16:0-7 Doxyl PC

Avanti Research - A Croda Brand 810602P, powder

别名:

1-palmitoyl-2-stearoyl-(7-doxyl)-sn-glycero-3-phosphocholine

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About This Item

经验公式(希尔记法):
C46H90N2O10P
分子量:
862.19
分類程式碼代碼:
41141825
NACRES:
NA.25

化驗

>99% (TLC)

形狀

powder

包裝

pkg of 1 × 1 mg (810602P-1mg)

製造商/商標名

Avanti Research - A Croda Brand 810602P

脂質類型

ESR probes
phospholipids

運輸包裝

dry ice

儲存溫度

−20°C

一般說明

Avanti′s nitroxide spin product listing is a group of compounds designed to act as membrane probes. A variety of positions down the hydrophobic chain are labeled with the nitroxide functional groups to allow probing the membrane at various depths. These compounds have been synthesized from 1-palmitoyl-2-hydroxy-sn-glycerol-3-phosphocholine with the product being purified by column chromatography. Various n-doxyl phosphocholines have been recently used as biophysical tools to elucidate membrane trafficking with phosphatidylinositol transfer proteins and as fluorescent quenchers in lipid bilayer structural studies.
Phosphatidylcholine (PC), a strong bilayer-forming lipid is the most common phospholipid in mammalian membranes. Several prokaryotic and eukaryotic pathogens has phosphorylcholine as its structural constituent.

生化/生理作用

Phosphorylcholine (PC) possesses immunomodulatory properties.

包裝

5 mL Clear Glass Sealed Ampule (810602P-1mg)

準備報告

Product use: To prevent aggregation, prepare water-based solutions of 2 mM stock solutions of n-DOXYL PCs and store in plastic. Dilute stock solutions to 0.03- 0.1 mM solutions for EPR studies. For liposome preparations in fluorescent quenching measurements, dissolve the doxyl lipid in 150 μl absolute ethanol for a concentration of 40.3 mM , Additional supplemental information.

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

儲存類別代碼

11 - Combustible Solids


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W Harnett et al.
Immunology today, 20(3), 125-129 (1999-04-22)
Phosphorylcholine (PC) is a structural component of a variety of prokaryotic and eukaryotic pathogens. In some cases, PC in infectious agents can benefit the infected host due to its targeting by both the innate and adaptive immune responses. However, as
Delivery of nitroxide spin label to cultured cells by liposomes
Chan HC
Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 8, 160-170 (1988)
Phosphatidylserine dynamics in cellular membranes.
Kay, J.G
Molecular Biology of the Cell, 23, 2198-2212 (2012)
Insight into antibody combining sites using nuclear magnetic resonance and spin label haptens
McConnell HM
Advances in Protein Chemistry, 49, 135-148 (1996)
Ultra-stable temperature control in EPR experiments: thermodynamics of gel-to-liquid phase transition in spin-labeled phospholipid bilayers and bilayer perturbations by spin labels
Alaouie AM, et. al.
Journal of Magnetic Resonance, 182, 229-238 (2006)

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