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化驗
>99% (TLC)
形狀
methylene chloride solution
包裝
pkg of 1 × 1 mL (700184M-1mg)
製造商／商標名
Avanti Research™ - A Croda Brand 700184M
濃度
1 mg/mL (700184M-1mg)
運輸包裝
dry ice
儲存溫度
−20°C
一般說明
Desmosterol is a precursor of cholesterol synthesis and the enzyme 24-dehydrocholesterol reductase catalyzes this step. It lacks a double bond between C24 and C25, which is present in cholesterol. Desmosterol is the major brain sterol and is localized in spermatozoa membrane and astrocytes. Desmosterol (D6) ester is a deuterated desmosterol with octadecanoic acid.
生化／生理作用
Desmosterol is a liver X receptor (LXR) agonist and it regulates inflammatory signaling in macrophages. Desmosterol accumulates during impairment of 24-dehydrocholesterol reductase enzyme thereby leading to desmosterolosis. It is a potential therapeutic target for treating the neurodegenerative disorder.
包裝
5 mL Clear Glass Sealed Ampule (700184M-1mg)
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
訊號詞
Warning
危險分類
Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Central nervous system
水污染物質分類（WGK）
WGK 2
Saara Vainio et al.
The Journal of biological chemistry, 281(1), 348-355 (2005-10-27)
Desmosterol is an immediate precursor of cholesterol in the Bloch pathway of sterol synthesis and an abundant membrane lipid in specific cell types. The significance of the difference between the two sterols, an additional double bond at position C24 in
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