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化驗
>99% (TLC)
形狀
powder
包裝
pkg of 1 × 1 mg (700116P-1mg)
製造商／商標名
Avanti Research™ - A Croda Brand 700116P
運輸包裝
dry ice
儲存溫度
−70°C
一般說明
7-脱氢胆固醇（7-DHC）是一种胆固醇前体，位于基底表皮角质形成细胞中。7DHC在紫外光B存在下发生光解生成维生素原D3。脱氢胆固醇还原酶（DHCR7）催化7-DHC的C（7-8）双键还原为胆固醇。7-脱氢胆固醇是7-脱氢胆固醇的氘代衍生物。
應用
7-脱氢胆固醇-d7已被用于：
- 作为内标物：加标衣藻CC-125脂质提取物进行质谱分析
- 用于培养细胞氧化甾醇分析的液相色谱-质谱（LC-MS）中
- 用于气相色谱/质谱（GC/MS）分析用于处理和标记SRD-1细胞（中国仓鼠卵巢（CHO）突变细胞系）
生化／生理作用
7-脱氢胆固醇（7-DHC）用作微生物维生素D3生产的前体。 7-脱氢胆固醇还原酶（DHCR7）功能受损导致7-DHC积累，并与Smith-Lemli-Opitz综合征（SLOS）有关。
包裝
5 mL琥珀色玻璃螺旋盖小瓶(700116P-1mg)
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Andrzej T Slominski et al.
PloS one, 4(2), e4309-e4309 (2009-02-05)
Since P450scc transforms 7-dehydrocholesterol (7DHC) to 7-dehydropregnenolone (7DHP) in vitro, we investigated sequential 7DHC metabolism by adrenal glands ex vivo. There was a rapid, time- and dose-dependent metabolism of 7DHC by adrenals from rats, pigs, rabbits and dogs with production
Hanul Kim et al.
Frontiers in microbiology, 6, 54-54 (2015-03-12)
Concern about global warming has prompted an intense interest in developing economical methods of producing biofuels. Microalgae provide a promising platform for biofuel production, because they accumulate high levels of lipids, and do not compete with food or feed sources.
Metabolic Precursor of Cholesterol Causes Formation of Chained Aggregates of Liquid-Ordered Domains.
Galya Staneva et al.
Langmuir : the ACS journal of surfaces and colloids, 32(6), 1591-1600 (2016-01-20)
7-Dehydrocholesterol, an immediate metabolic predecessor of cholesterol, can accumulate in tissues due to some metabolic abnormalities, causing an array of symptoms known as Smith-Lemli-Opitz syndrome. Enrichment of cellular membranes with 7-dehydrocholesterol interferes with normal cell-signaling processes, which involve interaction between
Hisako Akiyama et al.
Journal of lipid research, 57(11), 2061-2072 (2016-11-03)
To date, sterylglucosides have been reported to be present in various fungi, plants, and animals. In bacteria, such as Helicobacter pylori, proton NMR spectral analysis of isolated 1-O-cholesteryl-β-d-glucopyranoside (GlcChol) demonstrated the presence of an α-glucosidic linkage. By contrast, in animals
Josi Herron et al.
Current protocols in toxicology, 78(1), e65-e65 (2018-10-16)
Cholesterol and cholesterol-derived oxysterols are critical for embryonic development, synapse formation and function, and myelination, among other biological functions. Indeed, alterations in levels of cholesterol, sterol precursors, and oxysterols result in a variety of developmental disorders, emphasizing the importance of
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