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739960

Resomer^® RG 505，聚（D,L-丙交酯-co-乙交酯）

Name: Resomer<SUP>®</SUP> RG 505，聚（<SC>D,L</SC>-丙交酯-<I>co</I>-乙交酯）
Brand: ALDRICH

ester terminated, M_w 54,000-69,000

别名:

PLGA, RESOMER^® RG 505

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About This Item

线性分子式:

[C₃H₄O₂]_x[C₂H₂O₂]_y

CAS号:

26780-50-7

分類程式碼代碼:

12162002

NACRES:

NA.23

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形狀

amorphous

饋電比

lactide:glycolide 50:50

分子量

M_w 54,000-69,000

降解時間

<3 months

黏度

0.61-0.74 dL/g, 0.1 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer)

轉變溫度

T_g 48-52 °C

儲存溫度

2-8°C

InChI

1S/C6H8O4.C4H4O4/c1-3-5(7)10-4(2)6(8)9-3;5-3-1-7-4(6)2-8-3/h3-4H,1-2H3;1-2H2

InChI 密鑰

LCSKNASZPVZHEG-UHFFFAOYSA-N

一般說明

聚（丙交酯-乙交酯）（PLGA）是一种可生物降解的聚合物，用于制备聚合物微球。这些聚合物在体内通过其酯骨架水解为无毒产物而降解，这些无毒产物可由肾脏排出，或通过生物化学途径分解为CO₂和水。PLGA微球被广泛应用于包裹药物分子，并可用作长效缓释药物制剂。

應用

聚（丙交酯-乙交酯）（PLGA）可用于制造缓释药物递送体系，例如，它可用于包裹抗炎亲脂药物阿托伐他汀。

法律資訊

Evonik产品

RESOMER is a registered trademark of Evonik Rohm GmbH

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析证书(COA)

输入产品批号来搜索分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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Effect of water on exenatide acylation in poly(lactide-co-glycolide) microspheres.

Rongcai Liang et al.

International journal of pharmaceutics, 454(1), 344-353 (2013-07-23)

Peptide or protein degradation often occurs when water flows into the dosage form. The aim of this study was to investigate the effect of water on exenatide acylation in poly(lactide-co-glycolide) (PLGA) microspheres. Exenatide-loaded PLGA microspheres were incubated at different relative

Induction of long-lasting protective immunity against Toxoplasma gondii in BALB/c mice by recombinant surface antigen 1 protein encapsulated in poly (lactide-co-glycolide) microparticles.

Shu-Chun Chuang et al.

Parasites & vectors, 6, 34-34 (2013-02-13)

Current development efforts of subunit vaccines against Toxoplasma gondii, the etiological agent of toxoplasmosis, have been focused mainly on tachyzoite surface antigen 1 (SAG1). Since microparticles made from poly (lactide-co-glycolide) (PLG) polymers have been developed as safe, potent adjuvants or

Development of novel cationic chitosan-and anionic alginate-coated poly(D,L-lactide-co-glycolide) nanoparticles for controlled release and light protection of resveratrol.

Vanna Sanna et al.

International journal of nanomedicine, 7, 5501-5516 (2012-10-25)

Resveratrol, like other natural polyphenols, is an extremely photosensitive compound with low chemical stability, which limits the therapeutic application of its beneficial effects. The development of innovative formulation strategies, able to overcome physicochemical and pharmacokinetic limitations of this compound, may

Isoniazid loaded core shell nanoparticles derived from PLGA-PEG-PLGA tri-block copolymers: in vitro and in vivo drug release.

Mani Gajendiran et al.

Colloids and surfaces. B, Biointerfaces, 104, 107-115 (2013-01-10)

A series of biodegradable low molecular weight PLGA-PEG-PLGA tri-block copolymers have been synthesized in powder form. The anti-tuberculosis drug Isoniazid (INH) loaded polymeric core-shell nanoparticles (CSNPs) have been prepared by sonication followed by water-in-oil-in-water (w/o/w) double emulsification technique. The nanoparticles

Reduced postoperative chronic pain after tension-free inguinal hernia repair using absorbable sutures: a single-blind randomized clinical trial.

Igor Jeroukhimov et al.

Journal of the American College of Surgeons, 218(1), 102-107 (2013-11-12)

Chronic pain after inguinal hernia repair occurs in 16% to 62% of patients. The underlying mechanism probably involves sensory nerve damage and abnormal healing that might be influenced by the materials chosen for the procedure. We hypothesize that nonabsorbable sutures

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Resomer^® RG 505，聚（D,L-丙交酯-co-乙交酯）