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Merck

719897

Sigma-Aldrich

RESOMER® RG 502 H,聚(d,L-丙交酯--乙交酯)

acid terminated, viscosity 0.16-0.24 dL/g 

别名:

PLGA, RESOMER® RG 502 H

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About This Item

线性分子式:
[C3H4O2]x[C2H2O2]y
CAS号:
MDL號碼:
分類程式碼代碼:
12162002
NACRES:
NA.23

品質等級

形狀

amorphous

饋電比

lactide:glycolide 50:50

降解時間

<3 months

黏度

0.16-0.24 dL/g

轉變溫度

Tg 42-46 °C

儲存溫度

2-8°C

SMILES 字串

O2C(C(=O)OC(C2=O)C)C.O1CC(=O)OCC1=O

InChI

1S/C6H8O4.C4H4O4/c1-3-5(7)10-4(2)6(8)9-3;5-3-1-7-4(6)2-8-3/h3-4H,1-2H3;1-2H2

InChI 密鑰

LCSKNASZPVZHEG-UHFFFAOYSA-N

應用

聚((D,L-丙交酯-co-乙交酯)(PLGA)可用于:

  • 为H2S供体配制非水药物递送系统,以促进药物的持续释放。
  • 制备含有分散于 PLGA–PEG–PLGA聚合物凝胶中的更昔洛韦微球的聚合物混合物。该制剂可用作更昔洛韦药物的持续给药系统。
它也可用于制造释放一氧化氮的葡萄糖和乳酸传感器。

法律資訊

Evonik产品
RESOMER is a registered trademark of Evonik Rohm GmbH

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

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Diazeniumdiolate-doped poly (lactic-co-glycolic acid)-based nitric oxide releasing films as antibiofilm coatings.
Cai W,et al.
Biomaterials, 33(32), 7933-7944 (2012)
A Patil et al.
AAPS PharmSciTech, 18(6), 2291-2302 (2017-01-20)
Hydrogen sulfide (H2S) targets both underlying factors in glaucoma pathogenesis by reducing elevated intraocular pressure (IOP) and providing retinal neuroprotection, whereas the current clinical approaches targets only reducing IOP. Therefore, H2S could be a potential superior candidate for glaucoma pharmacotherapy.
Z Zhuang et al.
Journal of dental research, 98(2), 200-208 (2018-11-06)
Periodontitis is characterized by the progressive destruction of tooth-supporting alveolar bone, which is mainly caused by chronic inflammation in response to persistent bacterial insult. It has recently become clear that the pathogenesis of periodontitis is associated with a high ratio
Rongcai Liang et al.
International journal of pharmaceutics, 454(1), 344-353 (2013-07-23)
Peptide or protein degradation often occurs when water flows into the dosage form. The aim of this study was to investigate the effect of water on exenatide acylation in poly(lactide-co-glycolide) (PLGA) microspheres. Exenatide-loaded PLGA microspheres were incubated at different relative
Shu-Chun Chuang et al.
Parasites & vectors, 6, 34-34 (2013-02-13)
Current development efforts of subunit vaccines against Toxoplasma gondii, the etiological agent of toxoplasmosis, have been focused mainly on tachyzoite surface antigen 1 (SAG1). Since microparticles made from poly (lactide-co-glycolide) (PLG) polymers have been developed as safe, potent adjuvants or

商品

The world of commercial biomaterials has stagnated over the past 30 years as few materials have successfully transitioned from the bench to clinical use. Synthetic aliphatic polyesters have continued to dominate the field of resorbable biomaterials due to their long history and track record of approval with the U.S. Food and Drug Administration (FDA).

Aliphatic polyesters such as polylactide, poly(lactide-co-glycolide) and polycaprolactone, as well as their copolymers, represent a diverse family of synthetic biodegradable polymers that have been widely explored for medical uses and are commercially available.

Aliphatic polyesters such as polylactide, poly(lactide-co-glycolide) and polycaprolactone, as well as their copolymers, represent a diverse family of synthetic biodegradable polymers that have been widely explored for medical uses and are commercially available.

In the past two decades, tissue engineering and regenerative medicine have become important interdisciplinary fields that span biology, chemistry, engineering, and medicine.

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相关内容

Interest in utilizing biodegradable polymers for biomedical applications has grown since the 1960s.

Global Trade Item Number

货号GTIN
719897-5G4061835563708
719897-1G4061832855455

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