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反應適用性
reaction type: Grignard Reaction
品質等級
濃度
0.5 M in THF
bp
65 °C
密度
0.965 g/mL at 25 °C
儲存溫度
2-8°C
SMILES 字串
Fc1ccc([Mg]Br)cc1F
InChI
1S/C6H3F2.BrH.Mg/c7-5-3-1-2-4-6(5)8;;/h1,3-4H;1H;/q;;+1/p-1
InChI 密鑰
WZHAVYGMKGPNFN-UHFFFAOYSA-M
應用
3,4-Difluorophenylmagnesium bromide can be used:
- To prepare 3,4-difluorophenylboronic acid, a key building block employed in the synthesis of norepinephrine transporter selective molecules.
- In the synthesis of trimethoxybenzophenone derived tubulin polymerization inhibitors.
- In one of the key synthetic steps for the preparation of diarylketoxime derivatives as potent MCH-1R antagonists.
- In the synthesis of biologically important hydroxybupropion analogs useful in smoking cessation.
法律資訊
Rieke® Metals, Inc. 产品 ®Rieke Metals, Inc. 的注册商标
訊號詞
Danger
危險分類
Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
標靶器官
Respiratory system
安全危害
儲存類別代碼
3 - Flammable liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
1.0 °F - closed cup
閃點（°C）
-17.2 °C - closed cup
Synthesis and characterization of in vitro and in vivo profiles of hydroxybupropion analogues: aids to smoking cessation
Lukas RJ, et al.
Journal of Medicinal Chemistry, 53(12), 4731-4748 (2010)
Synthesis and monoamine transporter binding properties of 3α-(substituted phenyl) nortropane-2β-carboxylic acid methyl esters. Norepinephrine transporter selective compounds
Carroll FI, et al.
Journal of medicinal chemistry, 48(11), 3852-3857 (2005)
Discovery of novel diarylketoxime derivatives as selective and orally active melanin-concentrating hormone 1 receptor antagonists
Suzuki T, et al.
Bioorganic & medicinal chemistry letters, 19(18), 5339-5345 (2009)
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