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Merck

47619

Sigma-Aldrich

芴甲氧羰基-O-叔丁基-L-丝氨酸

≥98.0% (HPLC), for peptide synthesis

别名:

Fmoc-O-叔丁基-L-丝氨酸

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About This Item

经验公式(希尔记法):
C22H25NO5
CAS号:
分子量:
383.44
Beilstein:
3632013
EC號碼:
MDL號碼:
分類程式碼代碼:
12352209
eCl@ss:
32160406
PubChem物質ID:
NACRES:
NA.26

product name

芴甲氧羰基-O-叔丁基-L-丝氨酸, ≥98.0% (HPLC)

品質等級

化驗

≥98.0% (HPLC)

形狀

powder

光學活性

[α]20/D +25.5±1°, c = 1% in ethyl acetate

反應適用性

reaction type: Fmoc solid-phase peptide synthesis

應用

peptide synthesis

官能基

Fmoc

儲存溫度

2-8°C

SMILES 字串

CC(C)(C)OC[C@H](NC(=O)OCC1c2ccccc2-c3ccccc13)C(O)=O

InChI

1S/C22H25NO5/c1-22(2,3)28-13-19(20(24)25)23-21(26)27-12-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,12-13H2,1-3H3,(H,23,26)(H,24,25)/t19-/m0/s1

InChI 密鑰

REITVGIIZHFVGU-IBGZPJMESA-N

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應用

FMOC-O-叔丁基-L-丝氨酸是用于多肽合成的 N-末端保护试剂。一些已报道的应用实例有:
  • 通过化学选择性丝氨酸连接的环化反应,对抗生素达托霉素进行全合成。
  • 使用反复五氟苯酯介导的片段缩合制备MUC1,一种T细胞辅助多肽。
  • 泛素和双泛素的线性固相多肽合成。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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分析证书(COA)

Lot/Batch Number

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Wilkinson B L, et al.
Angewandte Chemie (International Edition in English), 50(7), 1635-1639 (2011)
Advances in proline ligation.
Townsend S D, et al.
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Chemical synthesis of ubiquitin, ubiquitin?based probes, and diubiquitin.
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The clearance of host cell proteins (HCPs) is of crucial importance in biomanufacturing, given their diversity in composition, structure, abundance, and occasional structural homology with the product. The current approach to HCP clearance in the manufacturing of monoclonal antibodies (mAbs)

商品

With a growing peptide drug market the fast, reliable and uncomplicated synthesis of peptides is of paramount importance.

With a growing peptide drug market the fast, reliable and uncomplicated synthesis of peptides is of paramount importance.

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