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Merck

47627

Sigma-Aldrich

Fmoc-Gly-OH

≥98.0% (T)

别名:

Fmoc-甘氨酸

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About This Item

经验公式(希尔记法):
C17H15NO4
CAS号:
分子量:
297.31
Beilstein:
2163967
EC號碼:
MDL號碼:
分類程式碼代碼:
12352209
eCl@ss:
32160406
PubChem物質ID:
NACRES:
NA.26

化驗

≥98.0% (T)

形狀

powder

反應適用性

reaction type: Fmoc solid-phase peptide synthesis

mp

174-175 °C (lit.)
174-178 °C

應用

peptide synthesis

官能基

Fmoc

儲存溫度

2-8°C

SMILES 字串

OC(=O)CNC(=O)OCC1c2ccccc2-c3ccccc13

InChI

1S/C17H15NO4/c19-16(20)9-18-17(21)22-10-15-13-7-3-1-5-11(13)12-6-2-4-8-14(12)15/h1-8,15H,9-10H2,(H,18,21)(H,19,20)

InChI 密鑰

NDKDFTQNXLHCGO-UHFFFAOYSA-N

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應用

  • Efficient Fmoc-Protected Amino Ester Hydrolysis Using Green Calcium (II) Iodide as a Protective Agent:研究在Fmoc-保护氨基酯的水解反应中采用环境友好的碘化钙,提高反应效率和可持续性(R Binette, M Desgagné, C Theaud, PL Boudreault - Molecules, 2022)。文章链接
  • α/β-Chimera peptide synthesis with cyclic β-sugar amino acids: the efficient coupling protocol:研究采用环β-糖氨基酸更好地合成α/β-嵌合肽,说明在药物化学的多肽设计中具有重要应用潜力(A Nagy, V Goldschmidt Gőz, I Pintér, V Farkas - Amino acids, 2019)。文章链接
  • MS, CD, and FT-IR characterization of five newly synthesized histidine-containing Ala-and Gly-based peptides:详细鉴定了新的含组氨酸多肽,说明对肽类药物开发有重要意义的技术(M Murariu, L Ion, CI Ciobanu, BA Petre - Rev. Roum Chem., 2017)。文章链接
  • Efficient method for the concentration determination of fmoc groups incorporated in the core-shell materials by Fmoc–glycine:详细说明了测定核壳材料中fmoc基团浓度的高效方法,对于先进功能材料的设计具有重要意义(E Szczepańska, B Grobelna, J Ryl, A Kulpa - Molecules, 2020)。文章链接
  • Circular aqueous fmoc/t‐bu solid‐phase peptide synthesis:探索了固相多肽合成的循环水相新方法,可能提供了更高效环保的肽合成方法(J Pawlas, JH Rasmussen - ChemSusChem, 2021)。文章链接

其他說明

糖类β-糖胺的fmoc-甘氨酸偶联,可用于低聚糖的分馏和新糖结合物的形成。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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Jing Fu et al.
Journal of hazardous materials, 368, 186-196 (2019-01-25)
Methyl-triclosan (MTCS), as a biodegradation product from antibacterial triclosan (TCS), has been detected in water catchments, and it has also been verified to accumulate in biota due to its hydrophobicity. There is a lack, however, of toxicity studies on MTCS
P H Naccache et al.
Blood, 84(2), 616-624 (1994-07-15)
The control of the adhesive properties of human neutrophils is an essential element of their defense function. One level at which this control is exerted involves the upregulation of the surface expression of beta 2-integrins. In this study, we have
Mario Fernández-Fernández et al.
Journal of mass spectrometry : JMS, 51(10), 980-987 (2016-07-09)
We have developed a novel, rapid and easy calculation procedure for Mass Isotopomer Distribution Analysis based on multiple linear regression which allows the simultaneous calculation of the precursor pool enrichment and the fraction of newly synthesized labelled proteins (fractional synthesis)
G Arsequell et al.
Analytical biochemistry, 216(1), 165-170 (1994-01-01)
We have devised a new saccharide derivatization scheme to provide not only the temporary attachment of a chromophore for detecting and facilitating the chromatographic separation of carbohydrates, but also the intermediates for further derivatization to produce neoglycoconjugates. Several neutral unprotected
Hyunjung Kim et al.
Journal of chromatography. A, 1097(1-2), 84-97 (2005-11-22)
The parameters of the thermodynamics and mass transfer kinetics of the structural analogues (L-enantiomers) of the template were measured on an Fmoc-L-tryptophan (Fmoc-L-Trp) imprinted polymer, at different temperatures. The equilibrium isotherm data and the overloaded band profiles of these compounds

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With a growing peptide drug market the fast, reliable and uncomplicated synthesis of peptides is of paramount importance.

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