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Merck

375160

Sigma-Aldrich

( S )-(+)-布洛芬

ReagentPlus®, 99%

别名:

S -(+)-IBU, (S)-(+)-2-(4-异丁基苯基)丙酸, (S)-(+)-4-异丁基-α-甲基苯乙酸

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About This Item

线性分子式:
(CH3)2CHCH2C6H4CH(CH3)CO2H
CAS号:
分子量:
206.28
Beilstein:
3590022
MDL號碼:
分類程式碼代碼:
12352002
PubChem物質ID:
NACRES:
NA.22

產品線

ReagentPlus®

化驗

99%

形狀

powder

光學活性

[α]20/D +59°, c = 2 in ethanol

mp

49-53 °C (lit.)

官能基

carboxylic acid

SMILES 字串

CC(C)Cc1ccc(cc1)[C@H](C)C(O)=O

InChI

1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)/t10-/m0/s1

InChI 密鑰

HEFNNWSXXWATRW-JTQLQIEISA-N

基因資訊

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一般說明

( S )-(+)-布洛芬是与布洛芬抗炎操作相关的对映体,布洛芬作为一种非甾体抗炎药,以外消旋形式被广泛使用。

應用

( S )-(+)-布洛芬可用作合成水凝胶的起始物料,具有通过酶介导水解释放的潜在能力。
用于药代动力学研究的抗炎药布洛芬的对映体。

法律資訊

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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F Jamali et al.
Journal of pharmaceutical sciences, 81(3), 221-225 (1992-03-01)
The influences of absorption rate and dosage size on the pharmacokinetics of ibuprofen (IB) enantiomers were studied in six healthy subjects. Rapidly absorbed solutions (50, 100, 200, 400, 600, and 1200 mg) and regular 600-mg tablets of racemic IB were
Enantioselective determination of ibuprofen in plasma by high-performance liquid chromatography-electrospray mass spectrometry.
Bonato PS, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 796(2), 413-420 (2003)
(S)-(+)-Ibuprofen-based hydrogelators: an approach toward anti-inflammatory drug delivery.
Bhuniya S, et al.
Tetrahedron Letters, 47(40), 7153-7156 (2006)
Youssef Harrak et al.
Journal of medicinal chemistry, 53(18), 6560-6571 (2010-09-02)
Following our previous research on anti-inflammatory drugs (NSAIDs), we report on the design and synthesis of 4-(aryloyl)phenyl methyl sulfones. These substances were characterized for their capacity to inhibit cyclooxygenase (COX-1 and COX-2) isoenzymes. Molecular modeling studies showed that the methylsulfone
Jennifer Manley et al.
The Annals of pharmacotherapy, 41(7), 1227-1232 (2007-05-24)
To evaluate the literature examining prophylactic use of acetaminophen and ibuprofen for prevention of adverse reactions associated with childhood immunization. Articles were identified via MEDLINE/PubMed/EMBASE (1966-March 2007) using the following key terms: vaccination, immunization, diphtheria-tetanus toxoids-whole pertussis (DTwP), diphtheria tetanus-toxoid

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