- Discovery and SAR of para-alkylthiophenoxyacetic acids as potent and selective PPARdelta agonists.
Discovery and SAR of para-alkylthiophenoxyacetic acids as potent and selective PPARdelta agonists.
Bioorganic & medicinal chemistry letters (2009-01-27)
Rui Zhang, Alan Deangelis, Aihua Wang, Ellen Sieber-McMaster, Xun Li, Ronald Russell, Patricia Pelton, Jun Xu, Peifang Zhu, Lubing Zhou, Keith Demarest, William V Murray, Gee-Hong Kuo
PMID19168353
ABSTRACT
Synthesis and SAR of para-alkylthiophenoxyacetic acids is described. Achiral compounds 30, 31 and 32 were identified as potent and selective PPARdelta agonists.
MATERIALS