- Curcumin is a potent DNA hypomethylation agent.
Curcumin is a potent DNA hypomethylation agent.
Bioorganic & medicinal chemistry letters (2008-12-30)
Zhongfa Liu, Zhiliang Xie, William Jones, Ryan E Pavlovicz, Shujun Liu, Jianhua Yu, Pui-kai Li, Jiayuh Lin, Jame R Fuchs, Guido Marcucci, Chenglong Li, Kenneth K Chan
PMID19112019
ABSTRACT
Molecular docking of the interaction of curcumin and DNMT1 suggested that curcumin covalently blocks the catalytic thiolate of C1226 of DNMT1 to exert its inhibitory effect. This was validated by showing that curcumin inhibits the activity of M. SssI with an IC(50) of 30 nM, but no inhibitory activity of hexahydrocurcumin up to 100 microM. In addition, curcumin can induce global DNA hypomethylation in a leukemia cell line.
MATERIALS