1096724

Carmustine

United States Pharmacopeia (USP) Reference Standard

• Synonym(s): 1,3-Bis(2-chloroethyl)-1-nitrosourea, BCNU
• Empirical Formula (Hill Notation): C₅H₉Cl₂N₃O₂
• CAS Number: 154-93-8
• Molecular Weight: 214.05
• MDL number: MFCD00057706
• UNSPSC Code: 41116107
• PubChem Substance ID: 329749246
• NACRES: NA.24

Properties

• grade: pharmaceutical primary standard
• API family: carmustine
• form: (Oily liquid to amorphous solid)
• manufacturer/tradename: USP
• mp: 30 °C (lit.)
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: −20°C
• SMILES string: ClCCNC(=O)N(CCCl)N=O
• InChI: 1S/C5H9Cl2N3O2/c6-1-3-8-5(11)10(9-12)4-2-7/h1-4H2,(H,8,11)
• InChI key: DLGOEMSEDOSKAD-UHFFFAOYSA-N
• Gene Information: human ... GSR(2936)

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

• Enhancing glioblastoma treatment: Overexpression of Let-7a-3p in U87MG glioblastoma cells enhances chemosensitivity to Carmustine, promoting autophagy and suppressing cell survival, suggesting its role in improving outcomes in glioblastoma multiforme treatment using antineoplastic alkylating compounds (Bahojb Mahdavi et al., 2024).


• Pharmacogenomic profiling in renal cancer: Characterization of mitoribosomal small subunit genes in renal cell carcinoma reveals significant implications for Carmustine′s pharmacogenomic interaction, enhancing understanding of its mechanism in cancer therapy and providing a basis for personalized treatment approaches (Wei et al., 2024).

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Safety Information

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H300,H350,H360
• pcodes: P201 - P280 - P301 + P330 + P331 + P310 - P308 + P313
• Hazard Classifications: Acute Tox. 2 Oral - Carc. 1B - Repr. 1B
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable