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Supelco

Supel™ BioSPME 96-Pin Device

pack of 1 ea

Synonym(s):

Supel™ BioSPME 96-Pin Device

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About This Item

UNSPSC Code:
41104018
NACRES:
NB.21

packaging

pack of 1 ea

Quality Level

100

technique(s)

solid phase microextraction (SPME): suitable

matrix active group

C18 coating

application(s)

clinical
pharmaceutical

compatibility

for use with automated robotic liquid handling systems

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General description

The Supel™ BioSPME 96-Pin Device combines BioSPME technology with high throughput free fraction determination for plasma protein binding studies and other free analyte analyses commonly performed by pharma and clinical laboratories. This fast, micro-sample prep device comprises a 96-pin universal format that fits into the wells of standard 96-well plates. The pins are coated with C18 particles and a patented binder that allows for small analytes of interest to bind, while larger macromolecules cannot. This extraction technique is shown to be more than three times faster than rapid equilibrium dialysis methods with improved data quality. Supel™ BioSPME 96-Pin Device workflow can be performed on automation robots via handling with standard gripper paddles, or alternatively can be achieved using a manual technique.

Analysis Note

small molecules having molecular weights up to 1 kDa and logP range from 1-5

Legal Information

Supel is a trademark of Sigma-Aldrich Co. LLC

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Articles

Protein Binding Determination - Comparison Study of Techniques & Devices

Comparative analysis of Supel™ BioSPME 96-Pin device with a rapid equilibrium dialysis technique for accuracy of measured values, sample cleanliness, and workflow time in drug protein binding.

Related Content

Supel™ BioSPME 96-Pin Devices

Supel™ BioSPME 96-Pin devices enhance the speed and simplicity of plasma protein binding studies and analyses of other free analytes, compared to the rapid equilibrium dialysis techniques for accurate and reproducible LCMS results.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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