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Key Documents

U9507

Sigma-Aldrich

Urocortin II mouse

Synonym(s):

UCN-II

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About This Item

CAS Number:
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.32

biological source

mouse

Quality Level

assay

≥97% (HPLC)

form

solid

technique(s)

immunohistochemistry: suitable

UniProt accession no.

storage temp.

−20°C

Gene Information

mouse ... Ucn2(171530)

Amino Acid Sequence

Val-Ile-Leu-Ser-Leu-Asp-Val-Pro-Ile-Gly-Leu-Leu-Arg-Ile-Leu-Leu-Glu-Gln-Ala-Arg-Tyr-Lys-Ala-Ala-Arg-Asn-Gln-Ala-Ala-Thr-Asn-Ala-Gln-Ile-Leu-Ala-His-Val-NH2

Application

Mouse urocortin II can be used for immunohistochemistry.

Biochem/physiol Actions

Urocortin II is a CRF-related neuropeptide having high affinity for CRF2 receptor. It stimulates protein kinase A through CRF2 receptor and increases the contractility in rabbit ventricular myocytes. It also facilitates pro-inflammatory effects in human intestinal cells through corticotropin-releasing hormone receptor 2α.
corticotropin-releasing factor (CRF) peptide

Other Notes

Lyophilized from 0.1% TFA in H2O

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Li-Zhen Yang et al.
Cardiovascular research, 69(2), 402-411 (2006-01-03)
Urocortin II (UcnII), a peptide of the corticotropin-releasing factor (CRF) family, exerts profound actions on the cardiovascular system. Direct effects of UcnII on adult cardiomyocytes have not been evaluated before. Our aim was to characterize functional effects of UcnII on
Alan C Moss et al.
Gut, 56(9), 1210-1217 (2007-04-07)
Urocortin II (UcnII) is a neuropeptide that binds with high affinity to the corticotropin-releasing hormone receptor 2 (CRHR2) in peripheral tissues. UcnII is synthesised in the intestine, but its role in human intestinal inflammation is largely unknown. Responses of human
Dimitri Tränkner et al.
Cell reports, 29(4), 791-799 (2019-10-24)
Aberrant microglia activity is associated with many neurological and psychiatric disorders, yet our knowledge about the pathological mechanisms is incomplete. Here, we describe a genetically defined microglia sublineage in mice which has the ability to suppress obsessive compulsion and anxiety symptoms. These
David P Burns et al.
Experimental physiology, 102(9), 1177-1193 (2017-07-01)
What is the central question of this study? We previously reported impaired upper airway dilator muscle function in the mdx mouse model of Duchenne muscular dystrophy (DMD). Our aim was to assess the effect of blocking interleukin-6 receptor signalling and
Patricia Tagliaferro et al.
The Journal of comparative neurology, 506(4), 616-626 (2007-12-11)
Interactions between stress and the mesocorticolimbic dopamine (DA) system have been suggested from behavioral and electrophysiological studies. Because corticotropin-releasing factor (CRF) plays a role in stress responses, we investigated possible interactions between neurons containing CRF and those producing DA in

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