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T6830

Sigma-Aldrich

Thyroglobulin human

Synonym(s):

Thyroglobulin human

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About This Item

CAS Number:
9010-34-8
EC Number:
232-721-3
MDL number:
MFCD01324794
UNSPSC Code:
12352202
NACRES:
NA.56

biological source

human

assay

≥95% (SDS-PAGE)

form

lyophilized solid

technique(s)

cell culture | mammalian: suitable

UniProt accession no.

P01266

storage temp.

2-8°C

Gene Information

human ... TG(7038)

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General description

Human Thyroglobulin (Tg) is a 660 kDa, dimeric protein produced by and used entirely within the thyroid gland. Human Thyroglobin is used by the thyroid gland to produce the thyroid hormones thyroxine (T4) and triiodothyryonine. Patients with Hashimoto′s thyroiditis or Grave′s disease, frequently develop antibodies against human Thyroglobulin.
Human Thyroglobulin (Tg) is a 660 kDa, dimeric protein produced by and used entirely within the thyroid gland. Human Thyroglobin is used by the thyroid gland to produce the thyroid hormones thyroxine (T4) and triiodothyryonine. Patients with Hashimoto′s thyroiditis or Graves′ disease, frequently develop antibodies against human Thyroglobulin. Thryoglobulin levels in the blood can be used as a tumor marker for certain kinds of thyroid cancer and in Graves′ disease.

Biochem/physiol Actions

Thyroglobulin has been shown to induce expression of platelet activating factor in human peripheral blood mononuclear cells which is found elevated in some patients with thyroid disease.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Ricardo Adaixo et al.
Nature communications, 13(1), 61-61 (2022-01-12)
The thyroglobulin (TG) protein is essential to thyroid hormone synthesis, plays a vital role in the regulation of metabolism, development and growth and serves as intraglandular iodine storage. Its architecture is conserved among vertebrates. Synthesis of triiodothyronine (T3) and thyroxine
E Resetkova et al.
Regional immunology, 4(4), 204-208 (1992-07-01)
Platelet activating factor (PAF), a phospholipid mediator, has been found to play a role in immune reactions, as well as in many pathophysiological alterations in certain disorders. To determine whether there might be a potential role of PAF in the
C Nascimento et al.
European journal of endocrinology, 169(5), 689-693 (2013-08-14)
Thyroglobulin (Tg) measurement is a major tool for the follow-up of differentiated thyroid cancer (DTC) patients; however, in patients who do not undergo radioactive iodine (RAI) ablation, normal ultrasensitive Tg levels measured under levothyroxine treatment (usTg/l-T4) are not well defined.
Rodrigo Moreno-Reyes et al.
The Journal of clinical endocrinology and metabolism, 98(9), 3694-3701 (2013-07-13)
Many countries in Europe remain mildly iodine deficient but relatively few country-level data exist on mild iodine deficiency (MID) and its impact on thyroid function in pregnant women. To determine the prevalence of thyroid disorders in pregnant women in Belgium
Sif Gudbrandsdottir et al.
Journal of immunology (Baltimore, Md. : 1950), 191(8), 4059-4067 (2013-09-21)
Activated platelets are known to modulate immune responses by secreting or shedding a range of immunomodulatory substances. We examined the influence of activated platelets on cytokine production by normal human mononuclear cells, induced by tetanus toxoid (TT), human thyroglobulin (TG)
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