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T6442

Sigma-Aldrich

Anti-TRPC6 antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Synonym(s):

Anti-Transient receptor potential cation channel, subfamily C, member 6 antibody produced in rabbit

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About This Item

MDL number:
MFCD02686669
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

mouse, rat

technique(s)

immunohistochemistry: suitable using mouse brain sections
western blot: 1:200-1:400 using rat brain or lung lysates

UniProt accession no.

Q61143

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TRPC6(7225)
mouse ... Trpc6(22068)
rat ... Trpc6(89823)

Immunogen

synthetic peptide (RRNESQDYLLMDELG) corresponding to amino acids residues 24-38 of mouse TRPC6. This sequence is identical in rat and highly homologous (15/16 residues identical) in human.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Chengkang He et al.
JCI insight, 7(5) (2022-01-26)
Currently, the most effective strategy for dealing with Alzheimer's disease (AD) is delaying the onset of dementia. Severe hypoglycemia is strongly associated with dementia; however, the effects of recurrent moderate hypoglycemia (RH) on the progression of cognitive deficits in patients
G Boulay et al.
The Journal of biological chemistry, 272(47), 29672-29680 (1997-12-31)
Hormonal stimulation of Gq-protein coupled receptors triggers Ca2+ mobilization from internal stores. This is followed by a Ca2+ entry through the plasma membrane. Drosophila Trp and Trpl proteins have been implicated in Ca2+ entry and three mammalian homologues of Drosophila
X Zhu et al.
Cell, 85(5), 661-671 (1996-05-31)
Capacitative calcium entry (CCE) describes CA2+ influx into cells that replenishes CA2+ stores emptied through the action of IP3 and other agents. It is an essential component of cellular responses to many hormones and growth factors. The molecular basis of
Yanna Du et al.
Molecular medicine reports, 16(2), 1117-1124 (2017-06-20)
Persistent pulmonary hypertension of the newborn (PPHN) is a life‑threatening disease that is commonly observed in the neonatal intensive care unit. PPHN is pathologically characterized by pulmonary vascular remodeling and, in particular, pulmonary artery smooth muscle cell (PASMC) proliferation. Decreased
Na+-independent, nifedipine-resistant rat afferent arteriolar Ca2+ responses to noradrenaline: possible role of TRPC channels.
Salomonsson, M., et al.
Acta Physiol., 200, 265-278 (2010)
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