T1573

Thrombin Receptor Activator Peptide 6

>95% (HPLC)

• Synonym(s): TRAP-6
• Empirical Formula (Hill Notation): C₃₄H₅₆N₁₀O₉
• CAS Number: 141136-83-6
• Molecular Weight: 748.87
• MDL number: MFCD00238172
• UNSPSC Code: 12352200
• PubChem Substance ID: 329826680
• NACRES: NA.77

Properties

• Quality Level: 200
• assay: >95% (HPLC)
• form: lyophilized
• technique(s): cell culture | mammalian: suitable
• solubility: 0.1% TFA: soluble; water: soluble
• UniProt accession no.: P25116
• storage temp.: −20°C
• SMILES string: CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(O)=O
• InChI: 1S/C34H56N10O9/c1-18(2)13-23(30(49)40-22(11-8-12-39-34(37)38)29(48)44-26(33(52)53)16-27(36)46)42-31(50)24(14-19(3)4)43-32(51)25(41-28(47)21(35)17-45)15-20-9-6-5-7-10-20/h5-7,9-10,18-19,21-26,45H,8,11-17,35H2,1-4H3,(H2,36,46)(H,40,49)(H,41,47)(H,42,50)(H,43,51)(H,44,48)(H,52,53)(H4,37,38,39)/t21-,22-,23-,24-,25-,26-/m0/s1
• InChI key: HAGOWCONESKMDW-FRSCJGFNSA-N
• Gene Information: human ... F2R(2149)

Description

Amino Acid Sequence

Ser-Phe-Leu-Leu-Arg-Asn

General description

Thrombin Receptor Activator Peptide 6 (TRAP-6) protects astrocytes from cell death, which is associated with hypoglycemia. TRAP-6 induced aggregation and impaired adhesion to collagen under flow conditions.

Application

Thrombin Receptor Activator Peptide 6 has been used to activate platelets in vitro. It has also been used to downregulate hippo signaling and increase nuclear yes-associated protein (YAP).

Biochem/physiol Actions

Hexapeptide fragment of the thrombin receptor (residues 42-47). Shown to activate the thrombin receptor and cause platelet aggregation (EC₅₀ = 0.8 μM).

Other Notes

Lyophilized from 0.1% TFA in H2O

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)