SRP6318

Kininogen,HMW from human plasma

≥95% (SDS-PAGE)

• Synonym(s): Alpha-2-thiol proteinase inhibitor, BDK, Fitzgerald factor, High molecular weight Kininogen, KNG, Kininogen-1 heavy chain, Kininogen-1 light chain, Low molecular weight growth-promoting, Lysyl-bradykinin, T-kinin Bradykinin, Williams-Fitzgerald-Flaujeac factor
• UNSPSC Code: 12352200
• NACRES: NA.32

Properties

• biological source: human plasma
• assay: ≥95% (SDS-PAGE)
• form: frozen liquid
• mol wt: 120 kDa
• packaging: pkg of 100 μg
• UniProt accession no.: P01042
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... KNG1(3827)

Description

General description

HMW kininogen, synthesized by hepatocytes, is a multifunctional protein. It is the precursor protein of bradykinin. In addition it is a cofactor in the activation of factor XI, XII, and prekallikrein and a major extra-cellular cysteine proteinase inhibitor. Kininogens inhibit systemic proteases which are thought to have a part in various diseases such as cancer, muscular dystrophy and joint disease.

Physical form

Frozen in 10 mM Na acetate, pH 5.5 with 250 mM NaCI.

Safety Information

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H315,H319,H334,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable