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SRP0382

Sigma-Aldrich

EZH2 /EED/SUZ12/RbAp48/AEBP2 human

recombinant, expressed in baculovirus infected Sf9 cells, ≥75% (SDS-PAGE)

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human

recombinant

expressed in baculovirus infected Sf9 cells

assay

≥75% (SDS-PAGE)

form

aqueous solution

mol wt

48 kDa (RbBP5)
51 kDa (EED)
53 kDa (AEBP2)
86 kDa (EZH2)
87 kDa (SUZ12)

packaging

pkg of 20 μg

shipped in

dry ice

storage temp.

−70°C

General description

Mutant version of EZH2 5 member complex, with a Tyr- to-Phe mutation on amino acids 646 of the EZH2 protein (GenBank Accession No. NM_004456). This mutation is often cited in the scientific literature as Y641F in variant 3 (GenBank Accession No. NM_001203247).

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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Ryan D Morin et al.
Nature genetics, 42(2), 181-185 (2010-01-19)
Follicular lymphoma (FL) and the GCB subtype of diffuse large B-cell lymphoma (DLBCL) derive from germinal center B cells. Targeted resequencing studies have revealed mutations in various genes encoding proteins in the NF-kappaB pathway that contribute to the activated B-cell

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