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SML3593

Sigma-Aldrich

Hexachlorophene

≥95% (HPLC)

Synonym(s):

2,2′,3,3′,5,5′-Hexachloro-6,6′-dihydroxydiphenylmethane, 2,2′-Dihydroxy-3,3′,5,5′,6,6′-hexachlorodiphenylmethane, 2,2′-Methylenebis[3,4,6-trichlorophenol], Nabac

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About This Item

Empirical Formula (Hill Notation):
C13H6Cl6O2
CAS Number:
70-30-4
Molecular Weight:
406.90
MDL number:
MFCD00002171
UNSPSC Code:
12352200
NACRES:
NA.04

Quality Level

100

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

ClC1=C(C(O)=C(C=C1Cl)Cl)CC2=C(C(Cl)=CC(Cl)=C2O)Cl

Biochem/physiol Actions

Hexachlorophene is selective and potent N-acyl-phosphatidylethanolamine phospholipase D (NAPE-PLD) inhibitor. Hexachlorophene potently inhibits NAPE-PLD activity in cultured HEK293 cells. Hexachlorophene is an antibacterial compound used topically by health-care personnel to control cutaneous gram-positive infections. Also it appears that hexachlorophene is an inhibitor of virus entry for Severe fever with thrombocytopenia syndrome virus (SFTSV).

pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Screening of an FDA-Approved Drug Library with a Two-Tier System Identifies an Entry Inhibitor of Severe Fever with Thrombocytopenia Syndrome Virus
Viruses, 11, 385-385 (2019)
Symmetrically substituted dichlorophenes inhibit N-acyl-phosphatidylethanolamine phospholipase D
The Journal of Biological Chemistry, 295(21), 7289-7300 (2020)

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