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Key Documents

SML3458

Sigma-Aldrich

KL-11743

≥98% (HPLC)

Synonym(s):

2-(3-(6-Ethoxy-4-((4-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)phenyl)amino)quinazolin-2-yl)phenoxy)-N-isopropylacetamide, 2-[3-[6-Ethoxy-4-[[4-(1H-pyrazol-4-yl)phenyl]amino]-2-quinazolinyl]phenoxy]-N-(1-methylethyl)acetamide

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About This Item

Empirical Formula (Hill Notation):
C30H30N6O3
CAS Number:
1369452-53-8
Molecular Weight:
522.60
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

KL-11743 is an orally available, potent inhibitor of class I glucose transporters that blocks glucose uptake in vitro and in vivo. It induces aspartate accumulation and increases mitochondrial metabolism. KL-11743 specifically inhibits the growth of tumors containing truncated the tricarboxylic acid (TCA) cycle due to mutations inactivating succinate dehydrogenase. Inhibition of glucose uptake by KL-11743 may synergize with therapies that induce oxidative stress (synthetic lethality).
orally available, potent inhibitor of class I glucose transporters that blocks glucose uptake in vitro and in vivo

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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