SML3108

Voclosporin

≥95% (HPLC)

• Synonym(s): 6-[(2S,3R,4R,6E)-3-Hydroxy-4-methyl-2-(methylamino)-6,8-nonadienoic acid]cyclosporin A, Cyclosporin A, 6-[(2S,3R,4R,6E)-3-hydroxy-4-methyl-2-(methylamino)-6,8-nonadienoic acid]-, ISATX247, LX 214, R 1524
• Empirical Formula (Hill Notation): C₆₃H₁₁₁N₁₁O₁₂
• CAS Number: 515814-01-4
• Molecular Weight: 1214.62
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: film or powder
• color: white to off-white
• storage temp.: −20°C
• InChI: 1S/C63H111N11O12/c1-25-27-28-29-41(15)53(76)52-57(80)66-44(26-2)59(82)68(18)34-49(75)69(19)45(30-35(3)4)56(79)67-50(39(11)12)62(85)70(20)46(31-36(5)6)55(78)64-42(16)54(77)65-43(17)58(81)71(21)47(32-37(7)8)60(83)72(22)48(33-38(9)10)61(84)73(23)51(40(13)14)63(86)74(52)24/h25,27-28,35-48,50-53,76H,1,26,29-34H2,2-24H3,(H,64,78)(H,65,77)(H,66,80)(H,67,79)/b28-27+/t41-,42+,43-,44+,45+,46+,47+,48+,50+,51+,52+,53-/m1/s1
• InChI key: BICRTLVBTLFLRD-PTWUADNWSA-N

Description

Biochem/physiol Actions

Voclosporin is a semi-synthetic calcineurin (CN) inhibitor that exhibits potent immunosuppressive activity.

Safety Information

• pictograms: GHS08
• signalword: Danger
• hcodes: H350,H361d
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Carc. 1B - Repr. 2
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable