SML2997
GHP-88309
≥98% (HPLC)
Synonym(s):
2-Fluoro-6-(5-isoquinolinyl)benzamide; 2-Fluoro-6-(5-isoquinolyl)benzamide, GHP 88309, GHP88309
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About This Item
Empirical Formula (Hill Notation):
C16H11FN2O
CAS Number:
Molecular Weight:
266.27
UNSPSC Code:
51111800
NACRES:
NA.77
Recommended Products
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
FC1=C(C(N)=O)C(C2=C(C=CN=C3)C3=CC=C2)=CC=C1
Biochem/physiol Actions
GHP-88309 is an orally available non-nucleoside paramyxovirus polymerase inhibitor with broad-spectrum anti-paramyxoviral activity (EC50 in μM= 0.4/HPIV3-JS, 0.8/HPIV3-5F6, 2/SeV-F1R-eGF, 0.6/MeV/Alaska.USA 16.00, 0.4/CDV-5804p) and little cytoxicity (CC50 >20μM). GHP-88309 potently inhibits the replication of HPIV1 isolate 5F6 and HPIV3 isolates 10L3 & 9R4 in 3D-ALI-HBTEC human airway organoids (EC50 = 280,90, 105 nM, respectively) in 3D-ALI-HBTECs. HPIV3 and provides complete protection against lethal Sendai virus infection in mice (150 mg/kg bid. po. starting at time of infection or 48 hrs after), a murine surrogate model of human HPIV3 disease.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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