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SML2150

Sigma-Aldrich

AZ6102

≥98% (HPLC)

Synonym(s):

rel-2-[4-[6-[(3R,5S)-3,5-Dimethyl-1-piperazinyl]-4-methyl-3-pyridinyl]phenyl]-3,7-dihydro-7-methyl-4H-pyrrolo[2,3-d]pyrimidin-4-one

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About This Item

Empirical Formula (Hill Notation):
C25H28N6O
CAS Number:
1645286-75-4
Molecular Weight:
428.53
UNSPSC Code:
12352200
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

CN1C=CC2=C1N=C(C3=CC=C(C4=CN=C(N5C[C@H](C)N[C@H](C)C5)C=C4C)C=C3)NC2=O

Biochem/physiol Actions

AZ6102 is a potent and selective Tankyrase 1/2 (TAMKS1/2) inhibitor that has 100-fold selectivity against other PARP family enzymes. AZ6102 is moderately orally bioavailable in rat and mice.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Jeffrey W Johannes et al.
ACS medicinal chemistry letters, 6(3), 254-259 (2015-03-31)
The canonical Wnt pathway plays an important role in embryonic development, adult tissue homeostasis, and cancer. Germline mutations of several Wnt pathway components, such as Axin, APC, and ß-catenin, can lead to oncogenesis. Inhibition of the poly(ADP-ribose) polymerase (PARP) catalytic

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