SML1607

Lesinurad

≥98% (HPLC)

• Synonym(s): 2-[[5-Bromo-4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl]thio]-acetic acid, RDEA 594
• Empirical Formula (Hill Notation): C₁₇H₁₄BrN₃O₂S
• CAS Number: 878672-00-5
• Molecular Weight: 404.28
• MDL number: MFCD22572730
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825493
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 25 mg/mL, clear
• storage temp.: −20°C
• SMILES string: BrC1=NN=C(SCC(O)=O)N1C2=C3C(C=CC=C3)=C(C4CC4)C=C2
• InChI: 1S/C17H14BrN3O2S/c18-16-19-20-17(24-9-15(22)23)21(16)14-8-7-11(10-5-6-10)12-3-1-2-4-13(12)14/h1-4,7-8,10H,5-6,9H2,(H,22,23)
• InChI key: FGQFOYHRJSUHMR-UHFFFAOYSA-N
• Gene Information: human ... SLC22A12(116085)

Description

Biochem/physiol Actions

Lesinurad is a selective inhibitor of Urate transporter 1 (URAT1), a urate-anion exchanger which is responsible for the majority of uric acid reabsorption from the renal tubular lumen. Lesinurad thus reduces serum uric acid levels. Lesinurad has been approved for use in combination with a xanthine oxidase inhibitor to treat hyperuricemia associated with gout.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable